Processing of Self versus Non-Self in Alzheimer's Disease.
Processing of Self versus Non-Self in Alzheimer's Disease.
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DOI：
10.3389/fnhum.2016.00097
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发表时间：
2016
影响因子：
2.9
通讯作者：
Warren JD
中科院分区：
文献类型：
--
作者：
Bond RL;Downey LE;Weston PS;Slattery CF;Clark CN;Macpherson K;Mummery CJ;Warren JD
尽管有相当多的证据表明阿尔茨海默病（AD）的自我意识异常，但AD自我加工改变的认知机制尚未完全确定。在这里，我们解决了这个问题的自我/非自我处理在三个AD患者的详细分析。我们设计了一种新型的神经心理学电池，包括触觉身体图式编码测试、触觉事件对自我与外部媒介的归因以及自我与非自我生成的声音信息的记忆，并与自我/非自我的日常生活测量相结合处理（人际反应指数）。研究了三名男性AD患者（年龄54-68岁;一名在早老素1基因中具有致病性突变，一名在淀粉样前体蛋白基因中具有致病性突变，以及一名具有支持潜在AD病理的CSF蛋白质谱）与一组八名健康老年男性个体（年龄58-74岁）的关系。与健康对照组相比，所有患者都有相对完整的触觉身体图式处理。与此相反，所有患者都表现出受损的记忆，以前提出的话，使用病人自己的声音，而记忆中的话，在其他声音不太一致的影响。两名患者表现出情绪感染水平的增加和人际反应指数的观点采择减少。我们的研究结果表明，AD可能与缺陷的自我/非自我分化随着时间的推移，尽管相对完整的身体形象：这种配置文件的改变自我处理与以前描述的赤字触觉身体图式与C9 orf 72突变相关的额颞叶痴呆症。我们将这些发现作为指导未来在更大患者队列中进行系统研究的初步依据。
Despite considerable evidence for abnormalities of self-awareness in Alzheimer’s disease (AD), the cognitive mechanisms of altered self-processing in AD have not been fully defined. Here we addressed this issue in a detailed analysis of self/non-self-processing in three patients with AD. We designed a novel neuropsychological battery comprising tests of tactile body schema coding, attribution of tactile events to self versus external agents, and memory for self- versus non-self-generated vocal information, administered in conjunction with a daily life measure of self/non-self-processing (the Interpersonal Reactivity Index). Three male AD patients (aged 54–68 years; one with a pathogenic mutation in the Presenilin 1 gene, one with a pathogenic mutation in the Amyloid Precursor Protein gene, and one with a CSF protein profile supporting underlying AD pathology) were studied in relation to a group of eight healthy older male individuals (aged 58–74 years). Compared to healthy controls, all patients had relatively intact tactile body schema processing. In contrast, all patients showed impaired memory for words previously presented using the patient’s own voice whereas memory for words presented in other voices was less consistently affected. Two patients showed increased levels of emotional contagion and reduced perspective taking on the Interpersonal Reactivity Index. Our findings suggest that AD may be associated with deficient self/non-self differentiation over time despite a relatively intact body image: this profile of altered self-processing contrasts with the deficit of tactile body schema previously described in frontotemporal dementia associated with C9orf72 mutations. We present these findings as a preliminary rationale to direct future systematic study in larger patient cohorts.