EFFECTS OF COLD AND HEAT ON BEHAVIOR AND CEREBELLAR FUNCTION IN GOLDFISH
EFFECTS OF COLD AND HEAT ON BEHAVIOR AND CEREBELLAR FUNCTION IN GOLDFISH
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DOI：
10.1007/bf00612674
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
PROSSER, CL
中科院分区：
文献类型：
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作者：
FRIEDLANDER, MJ;KOTCHABHAKDI, N;PROSSER, CL
无论是冷却还是加热，都观察到了类似的行为影响序列；大多数影响发生在整条鱼(Carassius Auratus)或只改变小脑的温度变化上。在适度加热或冷却时，鱼类过度兴奋，自发过度活跃；在进一步加热或冷却时，游泳不协调；当小脑下部结构加热或冷却时，平衡被破坏；当进一步加热或冷却时，昏迷和呼吸衰竭接踵而至。临界温度可以通过驯化来改变。小脑切除术的行为效应与运动中枢的温度效应是相加的。浦肯野神经元的电活动在与行为相同的温度范围内变化。通过小脑中间神经元的抑制是最敏感的，并且可以通过习服来改变。持续的活动随着升温到阻塞温度而增加；峰间间期直方图显示了升温期间的模式变化。通过苔藓纤维-颗粒细胞的激活比通过攀爬纤维的激活更敏感，而逆行冲动最具抵抗力。基于浦肯野神经元对运动中枢和平行反馈兴奋通路的抑制作用的神经元模型可以解释行为和电观察。[讨论了耐热性和耐寒性。]
A similar sequence of behavioral effects was observed for either cooling or heating; most effects occurred on changing temperature of entire fish [Carassius auratus] or of only the cerebellum. On moderate heating or cooling, fish are hyperexcitable, spontaneously hyperactive; on further heating or cooling swimming is uncoordinated; when the subcerebellar structures are heated or cooled, equilibrium is disturbed; on further heating or cooling coma and respiratory failure ensue. Critical temperatures are modifiable by acclimation. The behavioral effects of cerebellectomy are additive with temperature effects on motor centers. Electrical activity of Purkinje neurons changes in the same thermal ranges as behavior. Inhibition via cerebellar interneurons is most sensitive and can be modified by acclimation. Ongoing activity increases with warming up to a blocking temperature; interspike interval histograms show pattern changes during warming. Activation via mossy fibers-granule cells is more sensitive than that via climbing fibers, and antidromic impulses are most resistant. A neuronal model based on inhibitory actions of Purkinje neurons on motor centers and parallel feedback excitatory pathways can explain both behavioral and electrical observations. [Heat and cold tolerance are discussed.].