Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
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DOI：
10.1006/dbio.1996.0207
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发表时间：
1996-08-25
影响因子：
2.7
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Qiu, MS;Anderson, S;Rubenstein, JLR
EMX-1同源框基因的表达主要局限于发育和成熟的大脑皮层。为了研究它的功能，用基因打靶的方法产生了两个小鼠品系，它们的缺失包括EMX-1的N端编码区。纯合子缺失的小鼠是存活和可生育的，没有表现出明显的行为缺陷，然而，100%的纯合子小鼠缺乏大部分或全部的老茧，这是连接左右大脑半球的主要纤维束。杂合子表现为部分外显性，在突变的小鼠大脑皮质的组织学和各种分子特性是正常的。(C)1996年学术出版社。
Expression of the Emx-1 homeobox gene is largely restricted to the developing and mature cerebral cortex. To study its function, two lines of mice were generated using gene targeting methods that have a deletion that includes the N-terminal coding region of Emx-1. Mice homozygous for the deletion were viable and fertile and exhibited no obvious behavioral defects, However, 100% of homozygous mice lack most or all of their corpus callosum, the principle fiber tract that connects the left and right cerebral hemispheres. Heterozygotes show partial penetrance for the corpus callosum abnormality, The histology and various molecular properties of the cerebral cortex appear normal in the mutant mice. (C) 1996 Academic Press, Inc.