Compulsive drug use linked to sensitized ventral striatal dopamine transmission
Compulsive drug use linked to sensitized ventral striatal dopamine transmission
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DOI：
10.1002/ana.20822
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发表时间：
2006-05-01
影响因子：
11.2
通讯作者：
Piccini, P
中科院分区：
文献类型：
--
作者：
Evans, AH;Pavese, N;Piccini, P
目的：一小群帕金森病（PD）患者强迫使用多巴胺能药物，尽管会造成有害的社会，心理和身体影响，并符合核心诊断和统计手册（精神障碍）第四版物质依赖标准（多巴胺失调综合征[DDS]）。我们的目的是评估与PD control patients.Methods相比，左旋多巴诱导的多巴胺神经传递在纹状体的DDS患者：我们使用了两个扫描正电子发射断层扫描协议计算C-11-雷氯必利结合潜力的百分比变化从基线撤药（关闭药物）状态的结合潜力后，口服剂量的左旋多巴。我们与左旋多巴的主观影响，对内源性多巴胺释放的药理学挑战与左旋多巴在8个控制PD患者和8例DDS患者的影响。结果：PD患者DDS表现出增强的左旋多巴诱导腹侧纹状体多巴胺释放与左旋多巴治疗的PD患者没有nasively服用多巴胺能药物。致敏腹侧纹状体多巴胺神经传递产生的左旋多巴在这些人与自我报告的强迫性药物“想”，但不“喜欢”，并与提高psychological activation（punding）.Interpretation：这提供了证据，链接在人类的腹侧纹状体电路的敏感性强迫性药物的使用。
Objective: A small group of Parkinson's disease (PD) patients compulsively use dopaminergic drugs despite causing harmful social, psychological, and physical effects and fulfil core Diagnostic and Statistical Manual (of Mental Disorders) Fourth Edition criteria for substance dependence (dopamine dysregulation syndrome [DDS]). We aimed to evaluate levodopa-induced dopamine neurotransmission in the striatum of patients with DDS compared with PD control patients.Methods: We used a two-scan positron emission tomography protocol to calculate the percentage change in C-11-raclopride binding potential from a baseline withdrawal (off drug) state to the binding potential after an oral dose of levodopa. We related the subjective effects of levodopa to the effects on endogenous dopamine release of a pharmacological challenge with levodopa in eight control PD patients and eight patients with DDS.Results: PD patients with DDS exhibited enhanced levodopa-induced ventral striatal dopamine release compared with levodopatreated patients with PD not Compulsively taking dopaminergic drugs. The sensitized ventral striatal dopamine neurotransmission produced by levodopa in these individuals correlated with self-reported compulsive drug "wanting" but not "liking" and was related to heightened psychomotor activation (punding).Interpretation: This provides evidence that links sensitization of ventral striatal circuitry in humans to compulsive drug use.