Identifying brain regions for integrative sensorimotor processing with ankle movements
Identifying brain regions for integrative sensorimotor processing with ankle movements
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DOI：
10.1007/s00221-005-2335-5
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发表时间：
2005-09-01
影响因子：
2
通讯作者：
Thompson, AJ
中科院分区：
文献类型：
--
作者：
Ciccarelli, O;Toosy, AT;Thompson, AJ
本研究的目的是定义踝关节主动和被动运动过程中激活的皮质和皮质下结构，这些结构在运动生理学中发挥着基础作用，以提高我们对大脑感觉运动整合的理解。十六名健康受试者（均为右脚为主）使用定制的木制操作器执行足背屈跖屈任务，从而可以测量运动幅度。所有受试者都接受了包括表面肌电图在内的训练，并且能够在被动运动期间完全放松。评估了主动和被动运动期间的激活模式以及两种运动类型的功能性 MRI (fMRI) 反应之间的差异。通过联合分析识别主动和被动运动期间的共同激活区域。我们发现，被动运动激活的皮质区域通常在位置上与主动运动激活的皮质区域相似，尽管被动运动激活的程度更有限。在先前的研究中发现对运动规划很重要的某些区域（例如同侧初级运动皮层）中，双脚的主动运动比被动运动产生更大的激活。主动和被动运动过程中的共同激活不仅存在于对侧初级运动和感觉皮层，而且存在于运动前皮质区域（如双侧罗兰迪克盖和对侧辅助运动区）和皮质下区域（如同侧小脑和对侧壳核），表明这些区域参与踝关节运动的感觉运动整合。未来，使用被动运动的类似功能磁共振成像研究有可能阐明影响运动功能的中枢神经系统疾病中感觉运动整合的异常。
The objective of this study was to define cortical and subcortical structures activated during both active and passive movements of the ankle, which have a fundamental role in the physiology of locomotion, to improve our understanding of brain sensorimotor integration. Sixteen healthy subjects, all right-foot dominant, performed a dorsi-plantar flexion task of the foot using a custom-made wooden manipulandum, which enabled measurements of the movement amplitude. All subjects underwent a training session, which included surface electromyography, and were able to relax completely during passive movements. Patterns of activation during active and passive movements and differences between functional MRI (fMRI) responses for the two types of movement were assessed. Regions of common activation during the active and passive movements were identified by conjunction analysis. We found that passive movements activated cortical regions that were usually similar in location to those activated by active movements, although the extent of the activations was more limited with passive movements. Active movements of both feet generated greater activation than passive movements in some regions (such as the ipsilateral primary motor cortex) identified in previous studies as being important for motor planning. Common activations during active and passive movements were found not only in the contralateral primary motor and sensory cortices, but also in the premotor cortical regions (such as the bilateral rolandic operculum and contralateral supplementary motor area), and in the subcortical regions (such as the ipsilateral cerebellum and contralateral putamen), suggesting that these regions participate in sensorimotor integration for ankle movements. In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function.