Effects of immunosuppressive agents on Th17 cells involved in transplantation
Effects of immunosuppressive agents on Th17 cells involved in transplantation
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DOI：
10.1111/ctr.12043
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发表时间：
2013
影响因子：
2.1
通讯作者：
Xiao-fei Wang;J. V. van Velkinburgh;Yi Zhang;B. Ni;Zhanghui Yang
中科院分区：
文献类型：
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作者：
Xiao-fei Wang;J. V. van Velkinburgh;Yi Zhang;B. Ni;Zhanghui Yang
淋巴细胞衍生的辅助性T（Th）细胞是适应性免疫反应的关键调节因子，与炎症性疾病相关。最近认识到的Th细胞谱系，Th17，通过分泌促炎细胞因子白细胞介素17和募集产生活性氧（ROS）的单核细胞到感染部位，在宿主防御细胞外病原体中起着重要作用。然而，越来越多的证据表明，Th17细胞失调是一些免疫相关致病性疾病（包括同种异体移植排斥反应）的潜在原因。最近对人类移植患者的研究表明，Th17细胞对目前的免疫抑制疗法表现出抗性，否则这些免疫抑制疗法将防止同种异体移植物排斥。在这篇综述中，我们将讨论各种同种异体移植物中与Th17‐细胞功能相关的最新研究结果。
The lymphocyte‐derived helper T (Th) cells are critical regulators of the adaptive immune response and are associated with inflammatory disease. The most recently recognized Th‐cell lineage, Th17, plays an important role in host defense against extracellular pathogens by secreting the proinflammatory cytokine, interleukin 17, and recruiting reactive oxygen species (ROS)‐producing monocytes to the site of infection. However, accumulating evidence has implicated Th17‐cell dysregulation as an underlying cause for some immune‐related pathogenic conditions, including allograft rejection. Recent studies of human transplant patients have indicated that Th17 cells exhibit resistance to current immunosuppressive therapies that would otherwise prevent allograft rejection. In this review, we will discuss the most current research findings related to Th17‐cell function in various kinds of allografts.