Volumetric quantification of fibrous caps using intravascular optical coherence tomography.
Volumetric quantification of fibrous caps using intravascular optical coherence tomography.
复制标题
使用血管内光学相干断层扫描对纤维帽进行体积量化。
DOI：
10.1364/boe.3.001413
复制
发表时间：
2012-06-01
影响因子：
3.4
通讯作者：
Rollins AM
中科院分区：
文献类型：
--
作者：
Wang Z;Chamie D;Bezerra HG;Yamamoto H;Kanovsky J;Wilson DL;Costa MA;Rollins AM
The rupture of thin-cap fibroatheroma accounts for most acute coronary events. Optical Coherence Tomography (OCT) allows quantification of fibrous cap (FC) thickness in vivo. Conventional manual analysis, by visually determining the thinnest part of the FC is subject to inter-observer variability and does not capture the 3-D morphology of the FC. We propose and validate a computer-aided method that allows volumetric analysis of FC. The radial FC boundary is semi-automatically segmented using a dynamic programming algorithm. The thickness at every point of the FC boundary, along with 3-D morphology of the FC, can be quantified. The method was validated against three experienced OCT image analysts in 14 lipid-rich lesions. The proposed method may advance our understanding of the mechanisms behind plaque rupture and improve disease management.
