Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study
Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study
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DOI：
10.1016/s0140-6736(02)11280-3
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发表时间：
2002-10-19
期刊：
影响因子：
168.9
通讯作者：
van den Brandt, PA
中科院分区：
文献类型：
--
作者：
Hoek, G;Brunekreef, B;van den Brandt, PA
背景 在美国，长期暴露于颗粒物空气污染与心肺死亡率增加有关。我们的目的是评估荷兰饮食与癌症队列研究 (NLCS) 参与者的交通相关空气污染与死亡率之间的关系，这是一项正在进行的研究。方法我们从 1986 年至 1994 年的 NLCS 研究完整队列中随机抽取 5000 人（年龄 55-69 岁）进行调查。对 1986 年家庭住址的长期暴露于交通相关空气污染物（黑烟和二氧化氮）的情况进行了估计。暴露情况通过测量的区域和城市背景浓度以及主要道路附近居住的指标变量来表征。使用 Cox 比例风险模型评估暴露于空气污染和（特定原因）死亡率之间的关联，并调整潜在的混杂因素。结果显示，4492 名有数据的人中有 489 人（11%）在随访期间死亡。心肺死亡率与居住在主要道路附近有关（相对风险 1.95，95% CI 1.09-3.52），与估计的环境背景浓度（1.34，0.68-2.64）的一致性较差。居住在主要道路附近的总死亡相对风险为 1.41 (0.94-2.12)。非心肺、非肺癌死亡与空气污染无关（居住在主要道路附近为 1.03、0.54-1.96）。解释 长期暴露于与交通相关的空气污染可能会缩短预期寿命。
Background Long-term exposure to particulate matter air pollution has been associated with increased cardiopulmonary mortality in the USA. We aimed to assess the relation between traffic-related air pollution and mortality in participants of the Netherlands Cohort study on Diet and Cancer (NLCS), an ongoing study.Methods We investigated a random sample of 5000 people from the full cohort of the NLCS study (age 55-69 years) from 1986 to 1994. Long-term exposure to traffic-related air pollutants (black smoke and nitrogen dioxide) was estimated for the 1986 home address. Exposure was characterised with the measured regional and urban background concentration and an indicator variable for living near major roads. The association between exposure to air pollution and (cause specific) mortality was assessed with Cox's proportional hazards models, with adjustment for potential confounders.Findings 489 (11%) of 4492 people with data died during the follow-up period. Cardiopulmonary mortality was associated with living near a major road (relative risk 1.95, 95% CI 1.09-3.52) and, less consistently, with the estimated ambient background concentration (1.34, 0.68-2.64). The relative risk for living near a major road was 1.41 (0.94-2.12) for total deaths. Non-cardiopulmonary, non-lung cancer deaths were unrelated to air pollution (1.03, 0.54-1.96 for living near a major road).Interpretation Long-term exposure to traffic-related air pollution may shorten life expectancy.