Apparent diffusion coefficient and cerebrospinal fluid flow measurements in patients with hydrocephalus
Apparent diffusion coefficient and cerebrospinal fluid flow measurements in patients with hydrocephalus
复制标题
DOI：
10.1097/rct.0b013e31812f4edc
复制
发表时间：
2008-05-01
影响因子：
1.3
通讯作者：
Arslan, Arzu
中科院分区：
文献类型：
--
作者：
Anik, Yonca;Demirci, Ali;Arslan, Arzu
目的：评价弥散磁共振成像对脑积水患者治疗前后的疗效，并与脑脊液（CSF）流显像进行比较。方法：对20例脑积水患者（第1组，儿童，原发性导水管狭窄，n = 10；第2组，成人，正常压力脑积水，n = 10）和20名年龄匹配的健康受试者（作为对照）进行检查。脑脊液流速间隔计算为脑脊液流量测量中的峰值颅尾速度和尾颅速度的平均绝对值。通过扩散磁共振成像，评估了 8 个区域的表观扩散系数 (ADC) 值。结果：两组治疗后 ADC 值均显着下降（均 P < 0.001）。第1组术前平均脑脊液流速间隔值显着低于第2组术后及对照组（均P<0.001）。结论：脑积水患者ADC值升高，治疗后显着降低。术前 ADC 值可以作为基线，ADC 的变化可以作为对治疗和脑脊液流量测量的反应的指标。
Objective: To evaluate the efficacy of diffusion magnetic resonance imaging and compare with cerebrospinal fluid (CSF) flow imaging in patients with hydrocephalus before and after treatment.Methods: Twenty patients with hydrocephalus (group 1, pediatric, with primary aqueductal stenosis, n = 10; group 2, adult, with normal-pressure hydrocephalus, n = 10) and 20 age-matched healthy subjects that served as controls were examined. Cerebrospinal fluid flow velocity interval was calculated as the mean absolute values of the peak craniocaudal velocity and caudocranial velocity on CSF flow measurements. On diffusion magnetic resonance imaging, apparent diffusion coefficient (ADC) values from 8 regions were evaluated.Results: The decrease in ADC values after treatment was significant in both groups (P < 0.001 for both). Preoperative mean CSF flow velocity interval value was significantly lower in group 1 and significantly higher than postoperative and control group values in group 2 (P < 0.001 for all).Conclusion: The ADC values increase in hydrocephalus and decrease significantly after treatment. Preoperative ADC value may serve as baseline, and the change in ADC may be an indicator of response to treatment and CSF flow measurements.