Successful treatment of laryngeal leukoplakia by photodynamic therapy with local application of 5-aminolevulinic acid and 635 nm laser: A case report.
Successful treatment of laryngeal leukoplakia by photodynamic therapy with local application of 5-aminolevulinic acid and 635 nm laser: A case report.
复制标题
局部应用 5-氨基乙酰丙酸和 635 nm 激光光动力疗法成功治疗喉白斑：病例报告。
DOI：
10.1016/j.pdpdt.2022.102999
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发表时间：
2022
影响因子：
3.3
通讯作者：
Gelin Li
中科院分区：
文献类型：
--
作者：
Chi Zhang;Qian Hou;Hui Ren;Gelin Li
喉白斑是耳鼻喉科的常见病。目前，最广泛接受的治疗是在全身麻醉下进行支撑喉镜手术。我们报告一位67岁的男性患者，15年前被诊断为喉白斑，因其反复复发而接受了5次手术。光动力疗法采用5-氨基乙酰丙酸局部应用和635 nm半导体激光照射。术后随访6个月，无复发。局部应用5-ALA和635 nm激光的光动力疗法是安全的，耐受性良好。是一种有前途的治疗喉白斑的方法。
Laryngeal leukoplakia is a common disorder in otolaryngology. Presently, the most widely accepted treatment is suspension laryngoscopic surgery under general anesthesia. The high recurrence rate and hoarse voice after surgery make it an intractable disease to treat. Here we report a case of a 67-year-old man who was diagnosed of laryngeal leukoplakia 15 years ago and underwent 5 surgeries because of its repeated recurrences. Two sessions of photodynamic therapy were performed with local application of 5-aminolevulinic acid and irradiation of 635 nm diode laser. Complete response was observed and no recurrence was detected during follow-up of 6 months. Photodynamic therapy with local 5-ALA application and 635 nm laser is safe and well-tolerated. It is a promising modality for laryngeal leukoplakia.