Comments and controversies: Piecing together the neurobiology of decision-making.
Comments and controversies: Piecing together the neurobiology of decision-making.
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评论和争议：将决策的神经生物学拼凑在一起。
DOI：
10.1016/j.neuroimage.2015.07.089
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发表时间：
2016
期刊：
影响因子：
5.7
通讯作者：
Wand,GaryS
中科院分区：
文献类型：
--
作者：
Oswald,LynnM;Wand,GaryS
在本文中，我们解决了Tierney和Hart提出的问题（评估复杂的认知功能需要多个任务），以回应我们最近发表的研究结果，该研究表明，在爱荷华州赌博任务（IGT）中，不太有利的决策与静脉注射安非他明（Oswald等人，2015）的右腹纹状体多巴胺反应增强有关。我们同意该文件的总体前提，即决策涉及多个组成部分，这些组成部分可能无法通过单一措施加以利用。虽然Tierney和Hart也提出了一些与IGT结构有效性相关的重要问题，但我们认为，他们未能将这些发现放在越来越多的研究背景下，这些研究强调了DA功能在跨物种使用各种任务的冒险行为中的作用。还应该指出的是，我们的目标不是在单一研究的背景下“涵盖所有基础”。尽管如此，我们对讨论表示赞赏，我们认为这强调了对该结构进行进一步的经验改进的必要性，以促进对特定分子机制在组成过程中可能发挥的不同作用的检测和理解。
In this paper, we address issues raised by Tierney and Hart (Assessing Complex Cognitive Functioning Requires Multiple Tasks) in response to our recently published findings showing that less advantageous decision-making on the Iowa Gambling Task (IGT) was associated with enhanced right ventral striatal dopamine response to intravenous amphetamine (Oswald et al., 2015). We agree with the overall premise of the paper, which was that decision-making involves multiple components, which may not be tapped by a single measure. While Tierney and Hart also bring up some important issues related to the construct validity of the IGT, we suggest that they are failing to put the findings within the context of the growing body of research that has highlighted the role of DA function in risk-taking behavior across species using a variety of tasks. It should also be noted that it was not our goal to “cover all bases” within the context of a single study. Nevertheless, we appreciate the discussion, which we believe highlights the need for further empirical refinement of the construct to facilitate detection and understanding of the differential role that specific molecular mechanisms may play in the component processes.