High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma
High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma
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GRK3的高表达与胰腺导管腺癌的良好预后相关
DOI：
10.1016/j.prp.2017.11.013
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发表时间：
2018-02-01
影响因子：
2.8
通讯作者：
Zhao, Yu-Pei
中科院分区：
文献类型：
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作者：
Liu, Wen-Jing;Zhou, Li;Zhao, Yu-Pei
背景：人们发现 G 蛋白偶联受体激酶 3 (GRK3) 在某些癌症中发挥着关键的生物学作用。然而，其与胰腺导管腺癌 (PDAC) 临床病理特征和预后的关系仍不清楚。 & para;& para;方法和方法：使用基于组织微阵列的免疫组织化学方法，在 165 例 PDAC 根治性切除后的成对福尔马林固定石蜡包埋的肿瘤和非肿瘤样本中检测 GRK3 的表达，并进一步与临床病理参数和癌症特异性生存 (CSS) 相关。结果：GRK3在肿瘤组织中的表达量远低于非肿瘤组织。此外，GRK3在肿瘤组织中的表达与性别和T分期显着相关。单变量方面，GRK3 的高表达以及一些常规的临床病理变量可预测良好的 CSS。在多变量 Cox 回归测试中，GRK3 表达仍然是 PDAC 的重要预后标志物。最后，GRK3 与一些临床病理变量（尤其是 N 分期）相结合，获得了对 CSS 更精确的预测。结论：我们的数据表明 PDAC 中 GRK3 的表达下调，并且是一个独立的预后因素。
Background: It was found that G-protein-coupled receptor kinase 3 (GRK3) played key biological roles in some cancers. However, its associations with clinicopathologic features and prognosis in pancreatic ductal adenocarcinoma (PDAC) remain unknown.& para;& para; Methods and methods: Expression of GRK3 was detected, using tissue microarray-based immunohistochemistry, in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 165 patients with PDAC after curative resection, and was further correlated with clinicopathologic parameters and cancer-specific survival (CSS).& para;& para; Results: It was shown that GRK3 expression was much lower in tumor than in non-tumor tissues. Moreover, expression of GRK3 in tumor tissues was significantly associated with gender and T stage. Univariately, high GRK3 expression was predictive for favorable CSS, along with some conventional clinicopathologic variables. In multivariate Cox regression test, GRK3 expression remained to be a significant prognostic marker for PDAC. Finally, combination of GRK3 with some clinicopathologic variables, especially N stage, obtained more precise prediction for CSS.& para;& para; Conclusions: Our data suggested that expression of GRK3 was down-regulated in PDAC and was an independent prognostic factor.