Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.
Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.
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DOI：
10.1097/00004714-199910001-00003
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发表时间：
1999-10
影响因子：
2.9
通讯作者：
David J. Greenblatt;L. Moltke;J. Harmatz;R. Shader
中科院分区：
文献类型：
--
作者：
David J. Greenblatt;L. Moltke;J. Harmatz;R. Shader
选择性血清素再摄取抑制剂抗抑郁药在20世纪80年代中期的出现，引起临床精神药理学学科重新关注药物代谢和药物相互作用的主题。本文综述了一些较新的抗抑郁药的代谢谱，代谢特性的临床意义，以及可用于确定哪些特定的人类细胞色素P450 （CYP）介导代谢途径的研究方法。综述了各种新型抗抑郁药作为CYPs抑制剂的相对活性，以及体内和体外药物相互作用鉴定和定量方法的优缺点。
The appearance of selective serotonin reuptake inhibitor antidepressants in the mid-1980s caused the discipline of clinical psychopharmacology to refocus attention to the topics of drug metabolism and drug interactions. This article reviews the metabolic profiles of some newer antidepressants, the clinical implications of metabolic properties, and research methodology that can be applied in determining which specific human cytochromes P450 (CYP) mediate metabolic pathways. Also reviewed are the relative activities of various new antidepressants as inhibitors of CYPs, and the benefits and drawbacks of in vivo and in vitro methodologies for identification and quantitation of drug interactions.