Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents
Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents
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DOI：
10.1093/aje/kwg146
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发表时间：
2003-08-01
影响因子：
5
通讯作者：
Sinaiko, AR
中科院分区：
文献类型：
--
作者：
Steffen, LM;Jacobs, DR;Sinaiko, AR
作者检验了以下假设：青少年食用全谷物与胰岛素敏感性较高和体重指数（BMI）较低（体重（kg）/身高（m）（2））相关，并且这种关联在体重最重的青少年中更强。在平均年龄为13岁（标准差1.2）和15岁（标准差1.3）时，对285名明尼苏达州青少年进行了两次正常血糖胰岛素钳夹研究，作为评估胰岛素抵抗对不良心血管疾病危险因素发展影响的方案的一部分。全谷物的摄入量与BMI和胰岛素敏感性（以每分钟每公斤瘦体重（M-lbm）摄取的葡萄糖毫克数测量）的相关性进行了检查。在调整了年龄、性别、种族、坦纳分期和能量摄入后，青少年每天食用全麦食物少于（1）/（2）份的平均BMI为23.6，每天食用（1）/（2）-1（1）/（2）份的平均BMI为22.6，每天食用超过1（1）/（2）份的平均BMI为21.9（p=0.05）。校正年龄、性别、种族、坦纳分期、能量摄入、BMI和体力活动后，三个全谷物摄入组的M-lbm分别为11.6、12.3和13.2 mg/kg/min（p=0.02）。这种关系在BMI较高的青少年中更强（p=0.001）。全谷物摄入量与青少年的胰岛素敏感性和较低的BMI相关，特别是在最重的人中。
The authors tested the hypothesis that consumption of whole grain is associated with greater insulin sensitivity and lower body mass index (BMI) (weight (kg)/height (m)(2)) in adolescents and that this association is stronger among the heaviest adolescents. Two 127-item food frequency questionnaires were administered at the mean ages of 13 years (standard deviation 1.2) and 15 years (standard deviation 1.3) to 285 Minnesota adolescents who underwent two euglycemic insulin clamp studies 2 years apart as part of a protocol evaluating the influence of insulin resistance on development of adverse cardiovascular disease risk factors. Intake of whole grain was examined for associations with BMI and insulin sensitivity (measured as milligrams of glucose uptake per kilogram of lean body mass (M-lbm) per minute). After adjustment for age, gender, race, Tanner stage, and energy intake, mean BMI was 23.6 for adolescents consuming less than (1)/(2) serving/day of whole-grain foods, 22.6 for (1)/(2)-1(1)/(2) servings/day, and 21.9 for more than 1(1)/(2) servings/day (p=0.05). After adjustment for age, gender, race, Tanner stage, energy intake, BMI, and physical activity, M-lbm was 11.6, 12.3, and 13.2 mg/kg/minute, respectively, in the three whole grain intake groups (p=0.02). This relation was stronger among adolescents with higher BMIs (p=0.001). Whole grain intake was associated with greater insulin sensitivity and lower BMI in adolescents, especially among the heaviest persons.