Significance of heat shock protein-27 expression in patients with renal cell carcinoma
Significance of heat shock protein-27 expression in patients with renal cell carcinoma
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DOI：
10.1016/j.urology.2004.04.017
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发表时间：
2004-09-01
期刊：
影响因子：
2.1
通讯作者：
Kirkali, Z
中科院分区：
文献类型：
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作者：
Erkizan, Ö;Kirkali, G;Kirkali, Z
目标。探讨热休克蛋白-27(HSP-27)在肾癌中的表达及其生物学意义。HSPs最初被定义为热休克和其他环境和病理生理应激诱导的蛋白质。它们与蛋白质之间的相互作用有关，被认为在癌症中起着重要作用。HSP-27在一些人类肿瘤中的表达已被证实。应用免疫组织化学方法检测76例肾癌患者肿瘤组织和正常肾组织中HSP-27的表达。其结果与临床分期、淋巴结转移、组织学分级及生存期有关。在所研究的76例肾癌组织标本中，73例(96%)证实了HSP-27的存在。低表达10例(14%)，中等表达38例(50%)，高表达25例(33%)。HSP-27在肾癌组织中的表达高于癌旁肾组织(P
Objectives. To investigate heat shock protein (HSP)-27 expression in patients with renal cell carcinoma (RCC) and examine its biologic significance. HSPs were first defined as proteins induced by heat shock and other environmental and pathophysiologic stresses. They are implicated in protein-protein interactions and are thought to play an important role in cancer. The expression of HSP-27 has been demonstrated in some human tumors.Methods. The expression of HSP-27 was studied in tumor and normal parenchyma tissue specimens from 76 patients with RCC by immunohistochemistry. The findings were correlated with clinical stage, lymph node metastasis, histologic grade, and survival.Results. Of the 76 RCC tissue specimens studied, the presence of HSP-27 was demonstrated in 73 (96%). The expression was low in 10 patients (14%), intermediate in 38 (50%), and high in 25 (33%). HSP-27 expression was greater in RCC tissue compared with adjacent noncancerous renal tissue (P