Changes in brain met-enkephalin concentrations with peripheral CCK injections in Zucker rats.
Changes in brain met-enkephalin concentrations with peripheral CCK injections in Zucker rats.
复制标题
Zucker 大鼠外周 CCK 注射后大脑甲硫氨酸脑啡肽浓度的变化。
DOI：
10.1016/0031-9384(86)90354-9
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发表时间：
1986
影响因子：
2.9
通讯作者：
Della-Fera,MA
中科院分区：
文献类型：
--
作者：
McLaughlin,CL;Baile,CA;Della-Fera,MA
越来越多的证据表明，大脑中的肽在控制食物摄入方面很重要。阿片样物质和CCK肽的施用分别引起饥饿和饱腹感。为了评估这些肽的相互作用和它们在中枢神经系统中的作用，测定了外周给药CCK后大鼠下丘脑中甲硫氨酸脑啡肽的浓度;此外，还研究了进食、禁食和肥胖的影响。在CCK-与生理盐水注射大鼠的甲硫氨酸脑啡肽浓度降低室旁核（PVN），视交叉上核（SC），视上核（SON），背内侧下丘脑（DMH）和腹内侧下丘脑（VMH）。与禁食大鼠相比，进食大鼠下丘脑前部（AH）的甲硫氨酸脑啡肽浓度较高，SC较低;与瘦大鼠相比，肥胖大鼠AH、PVN、SC、SON、DMH、外侧下丘脑和VMH的浓度较高。这些结果表明，外周注射CCK可以降低脑内甲硫氨酸脑啡肽的浓度，并提示这些肽可能相互作用影响行为的机制。此外，研究结果支持的假设，这是典型的肥胖大鼠的暴食可能是由于甲硫氨酸脑啡肽浓度增加。
There is increasing evidence that peptides in the brain are important in the control of food intake. Administration of opioid and CCK peptides have elicited hunger and satiety, respectively. To evaluate the interaction of these peptides and their role in the central nervous system, concentrations of met-enkephalin were measured in the hypothalamus of rats following peripheral administration of CCK; in addition, effects of feeding and fasting and obesity were studied. In CCK- vs. saline-injected rats met-enkephalin concentrations were decreased in the paraventricular nucleus (PVN), suprachiasmatic nucleus (SC), supraoptic nucleus (SON), dorsomedial hypothalamus (DMH) and ventromedial hypothalamus (VMH). In fed compared with fasted rats met-enkephalin concentrations were higher in the anterior hypothalamus (AH) and lower in the SC; in obese compared with lean rats, concentrations were higher in the AH, PVN, SC, SON, DMH, lateral hypothalmus and VMH. These results show that peripheral injections of CCK can decrease concentrations of met-enkephalin in the brain and suggest a mechanism by which these peptides may interact to influence behavior. In addition, the findings support the hypothesis that the hyperphagia which is typical of obese rats may be due to increased concentrations of met-enkephalin.