2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease
2-D DIGE analysis implicates cytoskeletal abnormalities in psychiatric disease
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DOI：
10.1002/pmic.200900015
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发表时间：
2009-06-01
期刊：
影响因子：
3.4
通讯作者：
Cotter, David R.
中科院分区：
文献类型：
--
作者：
English, Jane A.;Dicker, Patrick;Cotter, David R.
精神疾病中白色物质变化的潜在机制尚不清楚。我们的目的是从斯坦利阵列收集的35名精神分裂症患者、35名双相情感障碍患者和35名对照受试者的背外侧前额叶皮层深层白色物质中检测差异蛋白质表达。我们使用2-D DIGE来分析大脑中蛋白质表达的变化。我们发现70个蛋白质点在疾病和对照受试者之间有显著差异表达（ANCOVA，p
The mechanisms underlying white matter changes in psychiatric disease are not known. We aimed to characterise the differential protein expression in deep white matter from the dorsolateral prefrontal cortex from 35 schizophrenia, 35 bipolar disorder, and 35 control subjects, from the Stanley Array Collection. We used 2-D DIGE to profile for protein expression changes in the brain. We found 70 protein spots to be significantly differentially expressed between disease and control subjects (ANCOVA, p