Diabetic retinopathy: Neuron protection as a therapeutic target
Diabetic retinopathy: Neuron protection as a therapeutic target
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DOI：
10.1016/j.biocel.2013.03.002
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发表时间：
2013-07-01
影响因子：
4
通讯作者：
Gillies, Mark
中科院分区：
文献类型：
--
作者：
Zhang, Xinyuan;Wang, Ningli;Gillies, Mark
糖尿病视网膜病变（DR）主要被认为是由高血糖引起的微血管疾病，其特征在于视网膜血管渗漏、黄斑水肿和视网膜前新生血管形成。视网膜电图、对比敏感度、视野计和色觉研究中越来越多的临床证据表明，神经元变化可能发生在临床可检测到的微血管病变之前。因此，可能有一个主要的神经退行性过程，这有助于在DR的视力丧失。神经元凋亡DR已在体内和体外的报告。因此，DR中的神经保护可能是有价值的治疗靶点。本文概述了DR发病机制中神经退行性变的最新概念，特别强调了其新治疗方法的潜力。(C)2013爱思唯尔有限公司保留所有权利。
Diabetic retinopathy (DR) has mainly been regarded as a microvascular disease that is caused by hyperglycaemia and characterized by retinal vascular leakage, macular oedema and preretinal neovascularisation. Increasing clinical evidence from electroretinographic, contrast sensitivity, perimetric, and colour vision studies suggest that neuronal changes may occur prior to clinically detectable microvasculopathy. Thus, there may be a primary neurodegenerative process which contributes to loss of vision in DR. Neuronal apoptosis in DR has been reported both in vivo and in vitro. Consequently, neuroprotection in DR may be a valuable therapeutic target. This review outlines the recent new concepts of neurodegeneration in the pathogenesis of DR, particularly emphasising its potential for new therapeutic approaches. (C) 2013 Elsevier Ltd. All rights reserved.