Spontaneous Oscillations of Elastic Contractile Materials with Turnover
Spontaneous Oscillations of Elastic Contractile Materials with Turnover
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DOI：
10.1103/physrevlett.113.148102
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发表时间：
2014-10-01
影响因子：
8.6
通讯作者：
Salbreux, Guillaume
中科院分区：
文献类型：
--
作者：
Dierkes, Kai;Sumi, Angughali;Salbreux, Guillaume
在许多生物系统中已经观察到由肌动球蛋白细胞骨架驱动的单个和集体细胞振荡。在这里，我们建议，这些振荡可以占一个通用的振荡器模型的材料翻转和收缩对弹性元件。作为一个例子，我们表明，在果蝇胚胎的背侧关闭，实验观察到的肌动球蛋白浓度和振荡细胞形状的变化，确实可以捕捉到这里研究的动态方程。我们还调查了集体动力学系综这样的收缩元素，并表明，粘性和摩擦损失的相对贡献产生不同的制度的集体振荡。考虑到产生力的分子之间的收缩元素的扩散，我们的理论框架预测行波的外观，类似于形态发生过程中观察到的肌动球蛋白波的传播。
Single and collective cellular oscillations driven by the actomyosin cytoskeleton have been observed in numerous biological systems. Here, we propose that these oscillations can be accounted for by a generic oscillator model of a material turning over and contracting against an elastic element. As an example, we show that during dorsal closure of the Drosophila embryo, experimentally observed changes in actomyosin concentration and oscillatory cell shape changes can, indeed, be captured by the dynamic equations studied here. We also investigate the collective dynamics of an ensemble of such contractile elements and show that the relative contribution of viscous and friction losses yields different regimes of collective oscillations. Taking into account the diffusion of force-producing molecules between contractile elements, our theoretical framework predicts the appearance of traveling waves, resembling the propagation of actomyosin waves observed during morphogenesis.