Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A
Disruption of adult expression of sexually selected traits by developmental exposure to bisphenol A
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DOI：
10.1073/pnas.1107958108
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发表时间：
2011-07-12
影响因子：
11.1
通讯作者：
Rosenfeld, Cheryl S.
中科院分区：
文献类型：
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作者：
Jasarevic, Eldin;Sieli, Paizlee T.;Rosenfeld, Cheryl S.
暴露于内分泌干扰化合物（EDCs），如双酚A（BPA），可能会对野生动物和人类造成不良健康影响，但关于哪些性状对EDCs最敏感，并可能作为暴露的晴雨表，仍存在争议。性选择性状的表达，通过交配和交配伴侣的间性竞争进化，比自然选择的性状更依赖于动物的发育和身体状况，因此可能特别容易受到发育暴露于内分泌干扰物的破坏。我们使用鹿鼠（Peromyscus maniculatus）作为模型来验证这一假设。在这个物种中，成年雄性对配偶的竞争得到了增强的空间导航和探索能力的支持，这使得雄性能够寻找潜在的、广泛分布的雌性。雄性鹿小鼠暴露于BPA或炔雌醇（EE）通过母体饮食没有表现出变化的外部表型，感觉发育，或成年循环浓度的睾酮和皮质酮，但空间学习能力和探索行为严重受损与对照组相比，男性。因为这些特征在女性中不是性选择的，BPA暴露可以预见没有影响，尽管EE暴露的女性表现出增强的空间导航能力。BPA暴露和对照组雌性动物都喜欢对照组雄性动物而不是BPA暴露雄性动物。我们证明，发育暴露于BPA会损害男性成功繁殖所必需的认知能力和行为，这对其他物种（包括我们自己）具有广泛的影响。因此，性选择性状可能提供有用的生物标志物，以评估动物和人类种群的环境污染风险。
Exposure to endocrine disrupting compounds (EDCs), such as bisphenol A (BPA), may cause adverse health effects in wildlife and humans, but controversy remains as to what traits are most sensitive to EDCs and might serve as barometers of exposure. Expression of sexually selected traits that have evolved through intrasexual competition for mates and intersexual choice of mating partner are more dependent on developmental and physical condition of an animal than naturally selected traits and thus might be particularly vulnerable to disruption by developmental exposure to EDCs. We have used the deer mouse (Peromyscus maniculatus) as a model to test this hypothesis. Adult male-male competition for mates in this species is supported by enhanced spatial navigational and exploratory abilities, which enable males to search for prospective, widely dispersed females. Male deer mice exposed to BPA or ethinyl estradiol (EE) through maternal diet showed no changes in external phenotype, sensory development, or adult circulating concentrations of testosterone and corticosterone, but spatial learning abilities and exploratory behaviors were severely compromised compared with control males. Because these traits are not sexually selected in females, BPA exposure predictably had no effect, although EE-exposed females demonstrated enhanced spatial navigational abilities. Both BPA-exposed and control females preferred control males to BPA-exposed males. Our demonstration that developmental exposure to BPA compromises cognitive abilities and behaviors essential for males to reproduce successfully has broad implications for other species, including our own. Thus, sexually selected traits might provide useful biomarkers to assess risk of environmental contamination in animal and human populations.