Iron deficiency and malaria among children living on the coast of Kenya
Iron deficiency and malaria among children living on the coast of Kenya
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DOI：
10.1086/422331
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发表时间：
2004-08-01
影响因子：
6.4
通讯作者：
Williams, TN
中科院分区：
文献类型：
--
作者：
Nyakeriga, AM;Troye-Blomberg, M;Williams, TN
缺铁和疟疾在撒哈拉以南非洲的大部分地区都很常见，这些疾病之间的相互作用很复杂。为了调查营养铁状况、免疫球蛋白和临床恶性疟原虫疟疾之间的关系，我们确定了一组生活在肯尼亚海岸的8个月至8岁儿童的疟疾发病率。生化铁的状态和疟疾特异性免疫反应，确定在2个横断面调查。我们发现，缺铁儿童的临床疟疾发病率明显较低（发病率比[IRR]，0.70; 95%可信区间[CI]，0.51-0.99; P
Both iron deficiency and malaria are common in much of sub-Saharan Africa, and the interaction between these conditions is complex. To investigate the association between nutritional iron status, immunoglobulins, and clinical Plasmodium falciparum malaria, we determined the incidence of malaria in a cohort of children between the ages of 8 months and 8 years who were living on the Kenyan coast. Biochemical iron status and malaria-specific immune responses were determined during 2 cross-sectional surveys. We found that the incidence of clinical malaria was significantly lower among iron-deficient children (incidence-rate ratio [IRR], 0.70; 95% confidence interval [CI], 0.51-0.99; P