Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants.
Increased Reporting Accuracy of Alzheimer Disease Symptoms in Caribbean Hispanic Informants.
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DOI：
10.1097/wad.0000000000000199
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发表时间：
2017-10
影响因子：
2.1
通讯作者：
Cosentino S
中科院分区：
文献类型：
--
作者：
Azar M;Zhu C;DeFeis B;Gu Y;Ornstein K;Lawless S;Cosentino S
症状的信息报告对于诊断和表征阿尔茨海默病（AD）是必不可少的。不同种族对痴呆症的认知和经验的差异可能会影响线人的报告。了解这种差异是至关重要的，因为在AD患者中，西班牙裔受影响不成比例。横断面分析检查了白人（n = 107）和加勒比海西班牙裔（n = 71）轻度AD的认知和功能症状的线人报告。为了探讨其准确性，线人报告的症状进行了比较，对病人的表现客观措施。调整后的分析显示，西班牙裔报告的症状比白人的线人。在两个种族中，症状的报告与患者的整体认知呈负相关。只有西班牙裔的症状报告与记忆和语言表现显着相关。告密者的症状报告与患者的整体认知相关，反映了两个种族群体中相对准确的告密者报告，并且在检查记忆和语言时，西班牙裔更强。这种差异可能反映了文化习俗和对痴呆症的看法，对诊断和治疗有影响。
Informant report of symptoms is essential for diagnosing and characterizing Alzheimer’s disease (AD). Differences in the perception and experience of dementia across ethnicities may influence informant report. Understanding such differences is critical given that among those with AD, Hispanics are disproportionately affected. Cross-sectional analyses examined informant report of cognitive and functional symptoms in mild AD across Caucasian (n=107) and Caribbean Hispanic (n=71) informants. To explore its accuracy, informant report of symptoms was compared against objective measures of patient performance. Adjusted analyses revealed Hispanics reported more symptoms than Caucasian informants. Informant report of symptoms was inversely correlated with patients’ global cognition in both ethnic groups. Only Hispanic report of symptoms was significantly associated with memory and language performance. Informant report of symptoms was associated with patients’ global cognition, reflecting relatively accurate informant reports in both ethnic groups, and was stronger in Hispanics when examining memory and language. Such differences may reflect cultural caregiving practices and perceptions of dementia, having implications for diagnosis and treatment.