Bubble nucleation and cooperativity in DNA melting
Bubble nucleation and cooperativity in DNA melting
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DOI：
10.1103/physrevlett.94.035504
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发表时间：
2005-01-28
影响因子：
8.6
通讯作者：
Bishop, AR
中科院分区：
文献类型：
--
作者：
Ares, S;Voulgarakis, NK;Bishop, AR
使用Peyrard-Bishop-Dauxois模型，通过Monte Carlo模拟，没有可调参数，研究了中间态（变性气泡）的发生及其在DNA熔融转变过程中的作用。与以前发表的实验结果发现良好的协议进行比较。熔化曲线，临界DNA段长度的气泡的稳定性，和两个状态的转变的可能性进行了研究。
The onset of intermediate states (denaturation bubbles) and their role during the melting transition of DNA are studied using the Peyrard-Bishop-Dauxois model by Monte Carlo simulations with no adjustable parameters. Comparison is made with previously published experimental results finding excellent agreement. Melting curves, critical DNA segment length for stability of bubbles, and the possibility of a two-state transition are studied.