Focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields
Focal cryogen insults for inducing segmental osteonecrosis: computational and experimental assessments of thermal fields
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DOI：
10.1016/s0021-9290(03)00154-4
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发表时间：
2003-09-01
影响因子：
2.4
通讯作者：
Conzemius, MG
中科院分区：
文献类型：
--
作者：
Reed, KL;Brown, TD;Conzemius, MG
股骨头坏死的矫形治疗是临床上常见的问题，目前还没有很好的解决办法。目前的动物模型不适合研究潜在的新解决方案，因为很难复制在人类疾病中看到的结构崩溃的自然历史。最近，发展到崩溃取得了冷冻诱导的骨坏死鸸鹋，虽然涉及的病变的大小或位置不精确控制。本文报道了一种新的冷冻损伤探针，其目的是在这种新的动物模型中提供良好的局部热损伤，同时最大限度地减少对非目标区域的损伤。有限元分析被用来阐明操作员控制的参数后的时间/空间变化的温度场的影响。数值公式包括归因于组织床灌注的对流热传递。计算结果与配套实验中的热电偶记录结果非常吻合。冷冻消融探针成功地在emu模型中产生了节段性损伤，其大小与计算的冷冻前直径相当。(C)2003爱思唯尔科技有限公司版权所有。
Orthopaedic management of femoral head osteonecrosis is a common clinical problem for which there presently is no good solution. Current animal models are inappropriate to study potential new solutions, since it has been difficult to replicate the natural history of structural collapse seen in the human disorder. Recently, progression to collapse was obtained for cryogenically induced osteonecrosis in emus, although the lesions involved were imprecisely controlled in terms of size or location. A new cryo-insult probe is here reported for the purpose of delivering well-prescribed local thermal insults in this new animal model, while minimizing damage to non-targeted regions. Finite element analysis was used to elucidate the influence of operator-controlled parameters upon the temporal/spatial variation of the thermal field. The numerical formulation includes convective heat transfer attributable to tissue bed perfusion. The computational results agreed closely with the results of thermocouple recordings in a companion bench-top experiment. The cryo-insult probe successfully produced segmental lesions in the emu model of sizes comparable to the computed freeze front diameters. (C) 2003 Elsevier Science Ltd. All rights reserved.