Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains
Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains
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DOI：
10.1016/j.devbrainres.2003.11.008
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发表时间：
2004-01-31
期刊：
影响因子：
--
通讯作者：
Kwak, S
中科院分区：
文献类型：
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作者：
Kawahara, Y;Ito, K;Kwak, S
在人脑中，GluR5 和 GluR6 中 Q/R 位点 RNA 编辑的发育上调很明显，但白质中的 GluR2 编辑下调。每个 ADAR mRNA 表达在灰质中均上调，而在白质中则受到不同程度的调节。 ADAR-2 mRNA 在唐氏综合症受试者的大脑中并未过度表达，也没有任何证据表明其 GluR 的 RNA 编辑效率发生变化。 (C) 2003 Elsevier B.V. 保留所有权利。
In human brain, developmental up-regulation in RNA editing at the Q/R site was evident in GluR5 and GluR6, but GluR2 editing in the white matter was down-regulated. Each ADAR mRNA expression was up-regulated in the gray matter, whereas differently regulated in the white matter. ADAR-2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs. (C) 2003 Elsevier B.V. All rights reserved.