Consequences of notch-mediated induction of Jagged1
Consequences of notch-mediated induction of Jagged1
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DOI：
10.1016/j.yexcr.2004.02.003
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发表时间：
2004-06-10
影响因子：
3.7
通讯作者：
Kadesch, T
中科院分区：
文献类型：
--
作者：
Ross, DA;Kadesch, T
Notch信号传导在表达Notch受体的细胞与表达配体的细胞接触时启动。在研究NIH 3T3细胞对表达Notch配体Jagged1的细胞的动态反应时，我们发现Notch信号转导导致配体Jagged1水平增加。诱导锯齿状蛋白1延迟相对于产生的活性刻缺蛋白和依赖于转录因子p63。诱导的Jagged1对Notch信号没有明显的自分泌作用，但可以促进幼稚细胞中的信号。这些结果描述了Notch信号可以在细胞之间传递的机制。(C)2004年爱思唯尔公司All rights reserved.
Notch signaling is initiated upon contact of cells expressing Notch receptors with those expressing ligands. While examining the dynamic response of NIH 3T3 cells to cells expressing the Notch ligand Jagged1, we found that Notch signaling resulted in increased levels of the ligand Jagged1. Induction of Jagged1 was delayed relative to the generation of active Notch and dependent on the transcription factor p63. The induced Jagged1 had no apparent autocrine effects on Notch signaling but could promote signaling in naive cells. These results describe a mechanism through which Notch signaling can be relayed from cell to cell. (C) 2004 Elsevier Inc. All rights reserved.