Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
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DOI：
10.1016/s1074-7613(02)00274-1
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发表时间：
2002-02-01
期刊：
影响因子：
32.4
通讯作者：
Bhan, AK
中科院分区：
文献类型：
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作者：
Mizoguchi, A;Mizoguchi, E;Bhan, AK
B细胞具有参与正常和异常免疫应答（包括自身免疫性疾病）的多种免疫功能。通过小鼠肠道炎症模型，我们在这里证明了一个B细胞亚群，诱导肠道相关淋巴组织，其特征是CD 1d上调。该B细胞亚群在慢性炎症环境下出现，产生IL-10，并通过下调与IL-1上调和STAT 3活化相关的炎性级联反应而不是通过改变极化的T辅助细胞应答来抑制肠道炎症的进展。这项研究表明，B细胞，通过产生细胞因子，如IL-10，可以作为调节细胞在免疫介导的炎症反应。
B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.