Distinct Familiarity-Based Response Patterns for Faces and Buildings in Perirhinal and Parahippocampal Cortex
Distinct Familiarity-Based Response Patterns for Faces and Buildings in Perirhinal and Parahippocampal Cortex
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DOI：
10.1523/jneurosci.0126-13.2013
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发表时间：
2013-06-26
影响因子：
5.3
通讯作者：
Koehler, Stefan
中科院分区：
文献类型：
--
作者：
Martin, Chris B.;McLean, David A.;Koehler, Stefan
在我们对内侧颞叶的理解中，一个尚未解决的问题是，与刺激类别有关的结构之间的功能差异如何与基于项目和基于上下文的记忆过程之间的区别有关。具体来说，目前还不清楚是否嗅周皮层（PrC）支持所有刺激类别的项目为基础的熟悉信号，或是否海马旁皮层（PhC）也可能发挥作用的刺激类别，已知从事这种结构在其他任务的背景。在这里，我们使用功能磁共振成像数据的多体素模式分析来比较与面孔、建筑物和椅子的感知熟悉度相关的人类活动模式。在扫描过程中，参与者从所有三个类别中判断以前研究过的和新的项目的熟悉程度。从所有分析中删除基于回忆的识别。在右PrC中，我们发现了区分熟悉面孔和陌生面孔的活动模式。相比之下，在右PhC中，我们观察到建筑物的这种模式。椅子的熟悉信号存在于两种结构中，但与在更细粒度的尺度上观察到的面部和建筑物的模式几乎没有重叠。在海马体中，我们没有发现任何物体类别的熟悉信号的证据。我们的研究结果表明，PrC和PhC有助于评估项目熟悉度。他们认为，PhC不仅代表情景背景，但也可以代表项目信息的某些对象类别的记忆决策。反过来，我们的研究结果也表明，参与的PrC在代表项目熟悉度是不是无处不在。
An unresolved question in our understanding of the medial temporal lobes is how functional differences between structures pertaining to stimulus category relate to the distinction between item-based and contextually based recognition-memory processes. Specifically, it remains unclear whether perirhinal cortex (PrC) supports item-based familiarity signals for all stimulus categories or whether parahippocampal cortex (PhC) may also play a role for stimulus categories that are known to engage this structure in other task contexts. Here, we used multivoxel pattern analyses of fMRI data to compare patterns of activity in humans that are associated with the perceived familiarity of faces, buildings, and chairs. During scanning, participants judged the familiarity of previously studied and novel items from all three categories. Instances in which recognition was based on recollection were removed from all analyses. In right PrC, we found patterns of activity that distinguished familiar from novel faces. By contrast, in right PhC, we observed such patterns for buildings. Familiarity signals for chairs were present in both structures but shared little overlap with the patterns observed for faces and buildings on a more fine-grained scale. In the hippocampus, we found no evidence for familiarity signals for any object category. Our findings show that both PrC and PhC contribute to the assessment of item familiarity. They suggest that PhC does not only represent episodic context but can also represent item information for some object categories in recognition-memory decisions. In turn, our findings also indicate that the involvement of PrC in representing item familiarity is not ubiquitous.