Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC):: A prospective follow-up study
Psychological consequences of predictive genetic testing for hereditary non-polyposis colorectal cancer (HNPCC):: A prospective follow-up study
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DOI：
10.1002/ijc.1372
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发表时间：
2001-08-15
影响因子：
6.4
通讯作者：
Kääriäinen, H
中科院分区：
文献类型：
--
作者：
Aktan-Collan, K;Haukkala, A;Kääriäinen, H
癌症的预测性基因检测可以识别那些有突变（突变阳性）的人，他们应该接受癌症监测，旨在早期发现癌症，以及那些没有突变（突变阴性）的人，他们不必要的担忧可以减轻，不需要经常接受监测，但是，预测性检测可能会对个人产生有害的情绪影响。在预测性基因检测过程中，我们评估了采用状态-特质焦虑量表（STAI）对271例遗传性非息肉病性结直肠癌（HNPCC）患者进行问卷调查，并在首次咨询前进行测量（基线），在测试披露会议上尽管在每次测量中，突变阳性个体比突变阴性个体更害怕癌症，但在两组中，对癌症的恐惧在披露后从基线显著下降，突变阳性的受试者在测试披露后立即比他们的同伴更焦虑，但在后续的研究中，这种差异已经消失。在其他变量中，未检测到由突变状态定义的组间差异或随时间的变化。我们的研究结果表明，咨询和测试减轻了对癌症的恐惧;在第一年的随访中没有发现有害的情绪影响。然而，为了证实这些发现，应该在更长的时间间隔后研究检测的影响，此外，为了评估这些结果的最终解释，需要研究癌症恐惧对突变阳性受试者的监测行为的影响。(C)2001 Wiley-Liss，Inc.
Predictive genetic testing for cancer allows identification of those with the mutation (mutation positive) who should undergo cancer surveillance aiming at early detection of cancer and those without the mutation (mutation negative), whose unnecessary worry can be alleviated and who need not undergo frequent surveillance, However, there is a risk that predictive testing might have a harmful emotional impact on an individual. In the course of a predictive genetic testing protocol, we assessed general anxiety (by the State-Trait Anxiety Inventory [STAI]), fear of cancer and death, satisfaction with life and attitude to the future using a questionnaire survey in 271 individuals tested for hereditary nonpolyposis colorectal cancer (HNPCC), Measurements were made before the first counseling (baseline), at the test disclosure session (STAI only) and I and IZ months after disclosure, Although at every measurement, the mutation-positive individuals were more afraid of cancer than those who were mutation negative, in both groups fear of cancer decreased significantly from baseline after disclosure, The mutation-positive subjects were more anxious than their counterparts immediately after the test disclosure, but the differences had disappeared at the follow-ups. In other variables, neither differences between the groups defined by mutation status nor changes with time were detected. Our findings suggest that counseling and testing relieve fear of cancer; no harmful emotional impact was detectable at the I-year follow-up. To confirm these findings, however, the impact of testing should be studied after a longer interval, Furthermore, to evaluate the ultimate interpretation of these results, studies are needed to investigate the impact of fear of cancer on surveillance behavior among the mutation-positive subjects. (C) 2001 Wiley-Liss, Inc.