Identification of hepatitis B virus indigenous to chimpanzees
Identification of hepatitis B virus indigenous to chimpanzees
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DOI：
10.1073/pnas.97.4.1661
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发表时间：
2000-02-15
影响因子：
11.1
通讯作者：
Robertson, BH
中科院分区：
文献类型：
--
作者：
Hu, XL;Margolis, HS;Robertson, BH
乙型肝炎病毒（HBV）及相关病毒属于肝病毒科，广泛存在于多种哺乳动物和鸟类中。虽然黑猩猩一直是HBV感染的主要实验模型，但该物种并未被认为是该病毒的天然宿主。对13只主要是野生捕获的感染慢性HBV的黑猩猩进行回顾性分析，在11只动物中发现了一种独特的黑猩猩HBV毒株。对HBV全基因组和乙型肝炎表面抗原（S基因）编码基因的核苷酸和衍生氨基酸分析确定了可用于可靠地鉴定黑猩猩HBV的序列模式。该分析表明，黑猩猩HBV不同于已知的人类HBV基因型，并且与先前从黑猩猩、长臂猿、大猩猩和猩猩中分离的HBV密切相关。
Hepatitis B viruses (HBV) and related viruses, classified in the Hepadnaviridae family, are found in a wide variety of mammals and birds. Although the chimpanzee has been the primary experimental model of HBV infection, this species has not been considered a natural host for the virus. Retrospective analysis of 13 predominantly wild-caught chimpanzees with chronic HBV infection identified a unique chimpanzee HBV strain in 11 animals. Nucleotide and derived amino acid analysis of the complete HBV genome and the gene coding for the hepatitis B surface antigen (S gene) identified sequence patterns that could be used to reliably identify chimpanzee HBV. This analysis indicated that chimpanzee HBV is distinct from known human HBV genotypes and is closely related to HBVs previously isolated from a chimpanzee, gibbons, gorillas, and orangutans.