VITAMIN-C INFLUENCE ON LOCALIZED ADJUVANT ARTHRITIS
VITAMIN-C INFLUENCE ON LOCALIZED ADJUVANT ARTHRITIS
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DOI：
10.7547/87507315-80-8-414
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发表时间：
1990-08-01
影响因子：
0.7
通讯作者：
ROUW, GR
中科院分区：
文献类型：
--
作者：
DAVIS, RH;ROSENTHAL, KY;ROUW, GR
这项工作试图确定维生素C对大鼠爪子局部诱导炎症和关节炎的影响，通过大鼠爪子肿胀、多形核白细胞浸润、疼痛和表面皮肤温度来测量。每天皮下注射150 mg/kg维生素C，持续20天，可减少关节炎肿胀，增加疼痛耐受性，减少多形核白细胞浸润，表面温度无明显变化。维生素C可为类风湿关节炎患者提供足部炎的补充或替代治疗。
This work attempts to determine the influence of vitamin C on locally induced inflammation and arthritis in rat paws, as measured by rat paw swelling, polymorphonuclear leukocyte infiltration, pain, and surface skin temperature. Daily subcutaneous administration of 150 mg/kg of vitamin C over 20 days reduced arthritic swelling, increased pain tolerance, and decreased polymorphonuclear leukocyte infiltration, with no significant change in surface temperature. Vitamin C may provide podiatritis with s supplemental or alternative treatment for patients with rheumatoid arthritis.