Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models.
Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models.
复制标题
食物和葡萄糖摄入后中央谷氨酸能状态的动态变化：人类和动物模型中的体内多模式评估。
DOI：
10.1177/0271678x211004150
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Higuchi M
中科院分区：
文献类型：
--
作者：
Kubota M;Kimura Y;Shimojo M;Takado Y;Duarte JM;Takuwa H;Seki C;Shimada H;Shinotoh H;Takahata K;Kitamura S;Moriguchi S;Tagai K;Obata T;Nakahara J;Tomita Y;Tokunaga M;Maeda J;Kawamura K;Zhang MR;Ichise M;Suhara T;Higuchi M
大脑中神经元活动的波动可能是神经功能改变的相对缓慢的组成部分的基础，这可以通过食物摄入和相关的全身代谢状态来调节。谷氨酸能神经传递在中枢神经系统兴奋性音调的调节中起着重要作用，尽管饮食元素如何对该系统的调节做出贡献仍然是难以捉摸的。在这里，我们提供了双峰正电子发射断层扫描（PET）和磁共振波谱（MRS），代谢型谷氨酸受体亚型5（mGluR5）的配体结合和谷氨酸水平在人脑中的动态改变的方式依赖于食物摄入量和随之而来的血糖水平的变化的第一个演示。在活体啮齿类动物中，分别通过PET、MRS和活体双光子显微镜进一步证实了全身葡萄糖给药后中枢mGluR5配体结合和谷氨酸水平的全脑调制以及深刻的神经元激活。目前的研究结果一致支持这样的观点，即食物相关的葡萄糖摄入量与大脑中的代谢能音调机械地相关，这在临床和非临床环境中通过双峰PET和MRS测量在体内是可预测的。
Fluctuations of neuronal activities in the brain may underlie relatively slow components of neurofunctional alterations, which can be modulated by food intake and related systemic metabolic statuses. Glutamatergic neurotransmission plays a major role in the regulation of excitatory tones in the central nervous system, although just how dietary elements contribute to the tuning of this system remains elusive. Here, we provide the first demonstration by bimodal positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) that metabotropic glutamate receptor subtype 5 (mGluR5) ligand binding and glutamate levels in human brains are dynamically altered in a manner dependent on food intake and consequent changes in plasma glucose levels. The brain-wide modulations of central mGluR5 ligand binding and glutamate levels and profound neuronal activations following systemic glucose administration were further proven by PET, MRS, and intravital two-photon microscopy, respectively, in living rodents. The present findings consistently support the notion that food-associated glucose intake is mechanistically linked to glutamatergic tones in the brain, which are translationally accessible in vivo by bimodal PET and MRS measurements in both clinical and non-clinical settings.