Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (West africa)
Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (West africa)
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DOI：
10.4269/ajtmh.2007.77.411
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发表时间：
2007-09-01
影响因子：
3.3
通讯作者：
Simondon, Kirsten B.
中科院分区：
文献类型：
--
作者：
Ntab, Balthazar;Cisse, Badara;Simondon, Kirsten B.
疟疾的负面影响可能是萨赫勒地区儿童营养状况季节性的原因。我们报告了一项随机、双盲、安慰剂对照试验，在1,063名塞内加尔学龄前儿童中进行季节性间歇性预防性抗疟治疗对生长和营养状况的影响。从9月至11月每月给予青蒿琥酯和磺胺嘧啶-乙胺嘧啶的组合。在干预组中，平均体重增加显著大于（122.9 +/- 340 vs 42.9 +/- 344 [SD] g/mo，P < 0.0001），三头肌和肩胛下皮褶厚度测量的损失较少（分别为-0.39 +/- 1.01与-0.66 +/- 1.01 mm/mo和-0.15 +/- 0.64与-0.36 +/- 0.62 mm/mo，P均< 0.0001）。身高增量无差异。对照组的消瘦患病率显著增加（治疗前为4.6%，治疗后为9.5%，P < 0.0001），但干预组儿童的消瘦患病率保持不变：5.6%，治疗后为7.0%（P = 0.62）。预防疟疾将改善季节性传播地区的儿童营养状况。
Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-con trolled trial of seasonal intermittent preventive anti-malarial treatment on growth and nutritional status in 1,063 Senegalese preschool children. A combination of artesunate and sulfadoxine-pyrimethamine was given monthly from September to November. In the intervention arm, mean weight gain was significantly greater (122.9 +/- 340 versus 42.9 +/- 344 [SD] g/mo, P < 0.0001) and losses in triceps and subscapular skinfold measurements were less (-0.39 +/- 1.01 versus -0.66 +/- 1.01 mm/mo, and -0.15 +/- 0.64 versus -0.36 +/- 0.62 mm/mo, respectively, P < 0.0001 for both). There was no difference in height increments. The prevalence of wasting increased significantly in the control arm (4.6% before versus 9.5% after, P < 0.0001), but remained constant in intervention children: 5.6% versus 7.0% (P = 0.62). The prevention of malaria would improve child nutritional status in areas with seasonal transmission.