Localized surface plasmon resonance (LSPR) based biosensors-猫眼课题宝

DOI：

10.32657/10356/65053

发表时间：

2015

期刊：

影响因子：

通讯作者：

中科院分区：

其他

文献类型：

作者：

Pengyu Chen

..............................................................................................................................我承认 ............................................................................................................第四列数据 ..................................................................................................................ix表列表 ................................................................................................................第23章1:介绍 ................................................................................................1 1.1背景 .........................................................................................................1 1.2动机 ...........................................................................................................3 1.3的目标 .............................................................................................................4 1.4假说 ..........................................................................................................4 1.5材料 .............................................................................................................5 1.6的方法 ...............................................................................................................5第二章:文献综述 ......................................................................................8 2.1生物传感器 ...........................................................................................................8 2.2局部表面等离子体共振 ...........................................................13 2.3形状和耦合的影响 .......................................................................16个2.4合成金纳米粒子 .....................................................................18 2.5折射率传感 ................................................................................21 2.6比色传感 .......................................................................................26日2.7基于表面增强拉曼散射的生物传感器 ...............................31日2.8评价LSPR峰值 ..............................................................................36 2.9基于石墨烯和石墨烯传感器 ..........................................................37 2.10若识别方案 .................................................................41 2.11简介的章节 ....................................................................45第三章：利用LSPR峰曲率的折射率传感......3.1传感原理：曲率与折射率的关系51 3.2曲率与传统峰移和消光技术的比较60 vii 3.3对小分子结合和生物传感器发展的响应............68年3.4实验部分 ......................................................................................73年3.5的结论 ......................................................................................................75第四章:配置对耦合的金纳米粒子的折射率灵敏度 .....................................................................................77年4.1配置的耦合AuNPs在二维平面上 ..........................................77年4.2实验部分 ......................................................................................84年4.3的结论 ......................................................................................................85年第五章:控制金纳米粒子的聚集和基质金属蛋白酶7 (MMP-7比色传感器 ) ................................................................86 5.1互补肽和盐的控制聚集......................86年5.2 MMP-7比色传感器 ....................................................................89年5.3实验部分 ....................................................................................101年5.4的结论 ....................................................................................................103第六章:向LSPR和喇曼混合传感 ....................................105年6.1 LSPR和喇曼混合传感芯片 ........................................................105年6.2实验部分 .....................................................................................118年6.3的结论 ....................................................................................................121第七章：等离子体和生物传感器的合作项目......................7.1比色传感器1：用于肉毒杆菌神经毒素A轻链比色检测的生物功能化金纳米颗粒..........................122年7.2比色传感器2:黄金aggredots比色G6PD缺乏症传感 ...................................................................................................................7.3比色传感器3：肽组装氧化石墨烯作为荧光开启传感器，用于特异性和敏感的脂多糖检测........127年7.4平台1:优化plasmonically耦合的金纳米粒子的折射率灵敏度 ..................................................................................129年7.5平台2:高密度金属nanogaps捏造固体基质用于表面增强拉曼散射 ....................................................131 -

.............................................................................................................................. i Acknowledgment ............................................................................................................ iv List of Figures .................................................................................................................. ix List of Tables ................................................................................................................ xxiii Chapter 1: Introduction ................................................................................................ 1 1.1 Background ......................................................................................................... 1 1.2 Motivation ........................................................................................................... 3 1.3 Objective ............................................................................................................. 4 1.4 Hypothesis .......................................................................................................... 4 1.5 Materials ............................................................................................................. 5 1.6 Methods ............................................................................................................... 5 Chapter 2: Literature Review ...................................................................................... 8 2.1 Biosensors ........................................................................................................... 8 2.2 Localized surface plasmon resonance ........................................................... 13 2.3 Effect of Shapes and Coupling....................................................................... 16 2.4 Synthesis of gold nanoparticles ..................................................................... 18 2.5 Refractive Index Sensing ................................................................................ 21 2.6 Colorimetric Sensing ....................................................................................... 26 2.7 Surface enhanced Raman scattering based biosensors ............................... 31 2.8 Evaluation of LSPR peaks .............................................................................. 36 2.9 Graphene and graphene based sensors .......................................................... 37 2.10 Biosensing Recognition Scheme ................................................................. 41 2.11 Synopsis of following chapters .................................................................... 45 Chapter 3: Refractive index sensing using the curvature of the LSPR peak ...... 50 3.1 Sensing principle: the relationship between curvature and refractive index51 3.2 Comparison of curvature to traditional peak shift and extinction techniques60 vii 3.3 Response to small molecule binding and biosensor development ............ 68 3.4 Experimental Section ...................................................................................... 73 3.5 Conclusions ...................................................................................................... 75 Chapter 4: Effect of Configurations on the Refractive index Sensitivity of Coupled Gold Nanoparticles ..................................................................................... 77 4.1 Configurations of coupled AuNPs on 2D plane .......................................... 77 4.2 Experimental Section ...................................................................................... 84 4.3 Conclusions ...................................................................................................... 85 Chapter 5: Controlled aggregation of gold nanoparticles and colorimetric Sensor for matrix metalloproteinase 7 (MMP-7) ................................................................ 86 5.1 Controlled aggregation by complementary peptide and salt ...................... 86 5.2 Colorimetric sensor for MMP-7 .................................................................... 89 5.3 Experimental Section .................................................................................... 101 5.4 Conclusions .................................................................................................... 103 Chapter 6: Towards a LSPR and Raman hybrid sensing .................................... 105 6.1 LSPR and Raman hybrid sensing chip ........................................................ 105 6.2 Experimental section ..................................................................................... 118 6.3 Conclusions .................................................................................................... 121 Chapter 7: Collaborative projects on plasmonics and biosensors ...................... 122 7.1 Colorimetric Sensor 1: Bio-functionalized gold nanoparticles for colorimetric sensing of botulinum neurotoxin A light chain .......................... 122 7.2 Colorimetric Sensor 2: Gold aggredots for colorimetric G6PD deficiency sensing ................................................................................................................... 125 7.3 Colorimetric Sensor 3: Peptide-assembled graphene oxide as fluorescent turn-on sensor for specific and sensitive lipopolysaccharide detection ........ 127 7.4 Platform 1: Optimizing the refractive index sensitivity of plasmonically coupled gold nanoparticles .................................................................................. 129 7.5 Platform 2: High-density metallic nanogaps fabricated on solid substrates used for surface enhanced Raman scattering .................................................... 131 -

Localized surface plasmon resonance (LSPR) based biosensors

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