FGF-7 (KERATINOCYTE GROWTH-FACTOR) EXPRESSION DURING MOUSE DEVELOPMENT SUGGESTS ROLES IN MYOGENESIS, FOREBRAIN REGIONALIZATION AND EPITHELIAL-MESENCHYMAL INTERACTIONS
FGF-7 (KERATINOCYTE GROWTH-FACTOR) EXPRESSION DURING MOUSE DEVELOPMENT SUGGESTS ROLES IN MYOGENESIS, FOREBRAIN REGIONALIZATION AND EPITHELIAL-MESENCHYMAL INTERACTIONS
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DOI：
10.1016/0925-4773(94)90050-7
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发表时间：
1994-01-01
影响因子：
2.6
通讯作者：
DICKSON, C
中科院分区：
文献类型：
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作者：
MASON, IJ;FULLERPACE, F;DICKSON, C
我们已经分离出小鼠FGF-7基因的cDNA和基因组克隆，并研究了其在整个发育过程中的表达。在发育中的心肌中瞬时检测到转录物，其在心房和心室之间差异调节。该基因也在体节的肌节中表达，与FGF-4和FGF-5转录物一致，并在裂解的肌肉中瞬时检测到。14.5 d.p.c.在发育中的前脑的脑室区检测到区域表达。在发育后期，在间充质组织中检测到FGF-7 RNA，表明其在上皮-间充质相互作用中的作用，并在真皮中检测到FGF-7 RNA，这与其作为角质形成细胞有丝分裂原的作用一致。我们的研究结果表明，FGF-7可能在发育过程中发挥多种作用。
We have isolated cDNA and genomic clones for the murine FGF-7 gene and examined its expression throughout development. Transcripts were transiently detected in the developing myocardium, differentially regulated between the atrium and ventricle. The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles. Regional expression was detected in the ventricular zone of the developing forebrain at 14.5 d.p.c. Later in development, FGF-7 RNA was detected in mesenchymal tissues suggesting a role in epithelial-mesenchymal interactions and in the dermis consistent with its proposed role as a keratinocyte mitogen. Our results suggest that FGF-7 is likely to have diverse roles during development.