Developmental timing in C-elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes
Developmental timing in C-elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes
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DOI：
10.1016/j.devcel.2004.12.006
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发表时间：
2005-02-01
影响因子：
11.8
通讯作者：
Slack, FJ
中科院分区：
文献类型：
--
作者：
Banerjee, D;Kwok, A;Slack, FJ
在秀丽隐杆线虫，异时基因构成一个发育定时器，指定时间细胞命运的选择。异时基因lin-42是C.果蝇和哺乳动物时期的elegans同源物，昼夜节律的关键调节器，其指定24小时昼夜周期内的行为和生理变化。我们显示了另外两个昼夜节律基因同源物，tim-1和kin-20，在发育计时器中的作用。沿着的还有lin-42、tim-1和kin-20。果蝇昼夜节律钟基因timeless和doubletime的elegans同源物分别是维持晚期幼虫身份和防止成体细胞命运的过早表达所必需的。昼夜节律和发育定时途径之间的分子相似性表明存在一种保守的分子机制，可用于不同类型的生物定时。
In Caenorhabditis elegans, heterochronic genes constitute a developmental timer that specifies temporal cell fate selection. The heterochronic gene lin-42 is the C. elegans homolog of Drosophila and mammalian period, key regulators of circadian rhythms, which specify changes in behavior and physiology over a 24 hr day/night cycle. We show a role for two other circadian gene homologs, tim-1 and kin-20, in the developmental timer. Along with lin-42, tim-1 and kin-20, the C. elegans homologs of the Drosophila circadian clock genes timeless and doubletime, respectively, are required to maintain late-larval identity and prevent premature expression of adult cell fates. The molecular parallels between circadian and developmental timing pathways suggest the existence of a conserved molecular mechanism that may be used for different types of biological timing.