For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses.
For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses.
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DOI：
10.1016/j.jmb.2016.04.030
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发表时间：
2016-08
影响因子：
5.6
通讯作者：
K. Patrick;S. Bell;R. Watson
中科院分区：
文献类型：
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作者：
K. Patrick;S. Bell;R. Watson
许多细胞内的细菌病原体以前认为保持密封在一个空泡可以识别的胞质先天免疫传感器。虽然已经在病毒感染的背景下表征了大量的胞质核酸传感器，但我们现在才开始研究这些相同的分子在细菌感染的背景下如何发挥作用。有趣的是，除了帮助宿主控制一些细胞内细菌的复制外，细菌DNA的胞质传感还涉及引发增强细菌存活和促进发病的免疫应答，这表明这些宿主DNA传感途径的激活是进化上保守的细菌适应。解开这些矛盾的先天免疫事件的机制细节对于理解它们如何影响细菌感染期间的整体免疫反应以及我们如何开发治疗方法以使平衡有利于宿主至关重要。
Many intracellular bacterial pathogens previously thought to remain sealed within a vacuole can be recognized by cytosolic innate immune sensors. While a wide array of cytosolic nucleic acid sensors have been characterized in the context of viral infection, we are only now beginning to examine how these same molecules function in the context of bacterial infection. Interestingly, in addition to helping the host control the replication of some intracellular bacteria, cytosolic sensing of bacterial DNA has also been implicated in eliciting immune responses that enhance bacterial survival and promote pathogenesis, suggesting that activation of these host DNA sensing pathways is an evolutionarily conserved bacterial adaptation. Unlocking the mechanistic detail of these paradoxical innate immune events will be crucial for understanding how they influence the overall immune response during bacterial infection and how we may develop therapeutics to tip the balance in favor of the host.