The Blood-Brain Barrier
The Blood-Brain Barrier
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DOI：
10.1101/cshperspect.a020412
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发表时间：
2015-01-01
影响因子：
7.2
通讯作者：
Prat, Alexandre
中科院分区：
文献类型：
--
作者：
Daneman, Richard;Prat, Alexandre
血管是将氧气和营养物质输送到全身所有组织和器官的关键。中枢神经系统(CNS)的血管具有独特的特性，称为血脑屏障，使这些血管能够严格调节离子、分子和细胞在血液和大脑之间的运动。这种对中枢神经系统稳态的精确控制允许适当的神经元功能，并保护神经组织免受毒素和病原体的影响，这些屏障属性的改变是不同神经系统疾病病理和进展的重要组成部分。生理屏障是由形成血管壁的内皮细胞(ECs)所拥有的一系列物理、运输和代谢特性来协调的，这些特性受到与不同的血管、免疫和神经细胞相互作用的调节。了解这些不同的细胞群体是如何相互作用来调节屏障属性的，对于了解大脑在健康和疾病期间的功能至关重要。
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central nervous system (CNS) possess unique properties, termed the blood-brain barrier, which allow these vessels to tightly regulate the movement of ions, molecules, and cells between the blood and the brain. This precise control of CNS homeostasis allows for proper neuronal function and also protects the neural tissue from toxins and pathogens, and alterations of these barrier properties are an important component of pathology and progression of different neurological diseases. The physiological barrier is coordinated by a series of physical, transport, and metabolic properties possessed by the endothelial cells (ECs) that form the walls of the blood vessels, and these properties are regulated by interactions with different vascular, immune, and neural cells. Understanding how these different cell populations interact to regulate the barrier properties is essential for understanding how the brain functions during health and disease.