Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.
Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.
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DOI：
10.1021/np100110u
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发表时间：
2010-06
影响因子：
5.1
通讯作者：
Xiao Luo;J. Pu;Wei‐Lie Xiao;Yong Zhao;Xue-mei Gao;Xiao-Nian Li;Haibo Zhang;Yuanyuan Wang;Yan Li
中科院分区：
文献类型：
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作者：
Xiao Luo;J. Pu;Wei‐Lie Xiao;Yong Zhao;Xue-mei Gao;Xiao-Nian Li;Haibo Zhang;Yuanyuan Wang;Yan Li
从冬凌草地上部分分离得到10个新的对位胡萝卜烷二萜化合物，异乌素A-J(1-10)和20个已知化合物。卢氏菌。通过波谱分析确定了化合物1-10的结构。对分离到的几个化合物进行了对HL-60、SMMC-7721、A-549、SK-BR-3和PANC-1人癌细胞的细胞毒性实验，其中一些化合物表现出较强的抑制活性。
Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.