The clinical characteristic of eight patients of COVID-19 with positive RT-PCR test after discharge
The clinical characteristic of eight patients of COVID-19 with positive RT-PCR test after discharge
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DOI：
10.1002/jmv.26017
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发表时间：
2020-06-02
影响因子：
12.7
通讯作者：
Liao, Wenhui
中科院分区：
文献类型：
--
作者：
Cao, Hong;Ruan, Lei;Liao, Wenhui
2019年冠状病毒病(新冠肺炎)是由严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)引起的。SARS-CoV-2在恢复期患者的实时逆转录聚合酶链式反应(RT-PCR)检测结果呈阳性的现象已有报道，对这类患者的研究较少。本研究对华中科技大学同济医院某病房2020年2月10日至4月13日收治的新冠肺炎患者的病历进行了回顾。2020年2月10日至4月13日，同济医院一病房收治新冠肺炎患者108例。其中8例因SARS-CoV-2 RT-PCR结果在出院后再次阳性而再次入院。第二次入院时，他们没有任何症状，胸部计算机断层扫描几乎正常。再次入院患者的实验室检测数据显示，所有8名患者的白细胞计数、淋巴细胞计数均正常。降钙素原、白介素6等炎症因子正常。经治疗，2名患者达标出院。其余6名患者因其SARS-CoV-2 RT-PCR未连续三次阴性而仍在医院接受治疗，其中2名患者的病程已持续90天以上。我们仍然需要警惕这些患者可能会感染其他人作为感染源，我们也需要警惕这些患者成为慢性病毒携带者。这也引发了我们对新冠肺炎排放标准的关注。
Corona virus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The phenomenon of positive real time reverse transcription polymerase chain reaction (RT-PCR) result of SARS-CoV-2 in recovered patients had occurred and the research about these patients was rare. In our study, we did a retrospective review of medical records from COVID-19 patients admitted to one ward of Tongji Hospital of Hua Zhong University of Science and Technology from 10 February to 13 April 2020. From 10 February to 13 April 2020, there were 108 patients of COVID-19 admitted in the one ward of Tongji Hospital. Among them, eight cases were readmission patients because the RT-PCR result of SARS-CoV-2 was positive again after discharge. On the second admission, they had no symptoms and their chest computed tomography was almost normal. Data from laboratory tests of the readmission patients showed that all eight patients had normal white blood cell count, lymphocyte count. The inflammatory factors like procalcitonin and interleukin 6 were normal. After treatment, two patients met the standard and were discharged. The other six patients were still in the hospital because their RT-PCR of SARS-CoV-2 did not get three consecutive negative results and the course of two patients had persisted more than 90 days. We still needed to be alert that these patients could infect other people as a source of infection, and we also needed to be alert that these patients become chronic virus carriers. It also aroused our concern about the discharge standard of COVID-19.