Highly Enantioselective Asymmetric Hydrogenation of Carboxy-Directed α,α-Disubstituted Terminal Olefins via the Ion Pair Noncovalent Interaction.
Highly Enantioselective Asymmetric Hydrogenation of Carboxy-Directed α,α-Disubstituted Terminal Olefins via the Ion Pair Noncovalent Interaction.
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DOI：
10.1021/acs.orglett.7b02972
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发表时间：
2017-11
期刊：
影响因子：
5.2
通讯作者：
Songwei Wen;Caiyou Chen;Shuaichen Du;Zhefan Zhang;Yi Huang;Zhengyu Han;Xiuqin Dong;Xumu Zhang
中科院分区：
文献类型：
--
作者：
Songwei Wen;Caiyou Chen;Shuaichen Du;Zhefan Zhang;Yi Huang;Zhengyu Han;Xiuqin Dong;Xumu Zhang
The t-Bu-Wudaphos was successfully applied into Rh-catalyzed asymmetric hydrogenation of α,α-disubstituted terminal olefins bearing a carboxy-directed group with excellent reactivities and enantioselectivities via the ion pair noncovalent interaction (up to >99% conversion, 98% yield, 98% ee) under mild reaction conditions without base. In addition, control experiments were conducted, and the results demonstrated that the ion pair noncovalent interaction between ligand and substrate played an important role in achieving an outstanding performance in this asymmetric hydrogenation.
