The Immune System and AMD.
The Immune System and AMD.
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DOI：
10.1007/s40135-013-0037-x
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发表时间：
2014-03-01
影响因子：
0.9
通讯作者：
Kleinman ME
中科院分区：
文献类型：
--
作者：
Frederick PA;Kleinman ME
年龄相关性黄斑变性(AMD)是一种复杂的、多因素的疾病，尚未完全了解。在基础和临床科学方面的重大努力已经揭示了在这种疾病的发病机制中似乎至关重要的许多领域。替代补体途径、免疫细胞激活和自身免疫都是怀疑这种疾病的免疫学起源的重要主题。在开发疾病监测和治疗的新技术方面，朝着完全了解这些过程的方向发展是重要的。
Age related macular degeneration (AMD) is a complex, multifactorial disease that has yet to be completely understood. Significant efforts in the basic and clinical sciences have unveiled numerous areas which appear to be critical in the pathogenesis of this disease. The alternative complement pathway, immune cell activation, and autoimmunity are all emerging as important themes to the suspected immunologic origins of this disease. Advancement toward a complete understanding of these processes is important in development of new techniques for disease monitoring and treatment.