Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory.
Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory.
复制标题
精氨酸加压素可预防与年龄相关的钠依赖性高亲和力胆碱吸收的增加和时间记忆内容的差异。
DOI：
10.1016/0014-2999(86)90287-6
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发表时间：
1986
影响因子：
5
通讯作者：
Wenk,GL
中科院分区：
文献类型：
--
作者：
Meck,WH;Church,RM;Wenk,GL
系统注射精氨酸抗利尿激素（AVP， 0.08压力单位/kg i.p.）给接受正强化时间任务训练的成熟大鼠（10-13个月），可以防止时间记忆内容的年龄相关差异和对照大鼠（27-30个月）额叶皮质钠依赖性高亲和胆碱摄取（SDHCU）的增加。AVP给药对海马和额叶皮质[3H]喹啉苄基酸（QNB）结合测量的毒蕈碱受体密度和胆碱乙酰转移酶（ChAT）水平均无影响。
Systematic injections of arginine vasopressin (AVP, 0.08 pressor units/kg i.p.) to mature rats (10–13 months) trained on a positively reinforced timing task prevented the age-related discrepancies in the content of temporal memory and the increases in sodium-dependent high affinity choline uptake (SDHCU) in the frontal cortex observed in control rats when the rats became aged (27–30 months). AVP administration had no effect on muscarinic receptor density as measured by [3H]quinuclidinyl benzilate (QNB) binding or on choline acetyltransferase (ChAT) levels in either the hippocampus or the frontal cortex.