Effect of anthrax immune globulin on response to BioThrax (anthrax vaccine adsorbed) in New Zealand white rabbits.
Effect of anthrax immune globulin on response to BioThrax (anthrax vaccine adsorbed) in New Zealand white rabbits.
复制标题
炭疽免疫球蛋白对新西兰白兔 BioThrax（吸附炭疽疫苗）反应的影响。
DOI：
10.1128/aac.00460-13
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发表时间：
2013
影响因子：
4.9
通讯作者：
Ionin,Boris
中科院分区：
文献类型：
--
作者：
Malkevich,NinaV;Basu,Subhendu;RudgeJr,ThomasL;Clement,KristinH;Chakrabarti,AjoyC;Aimes,RonaldT;Nabors,GaryS;Skiadopoulos,MarioH;Ionin,Boris
开发可在暴露后环境中同时使用的炭疽对策需要了解这些产品之间的相互作用。炭疽免疫球蛋白静脉注射（AIGIV）是一种候选的免疫治疗药物，含有针对炭疽毒素组成部分保护性抗原（PA）的中和抗体。我们评估了AIGIV与吸附炭疽疫苗biothrx在家兔体内的相互作用。虽然疫苗接种没有改变AIGIV的药代动力学，但在接种AIGIV的动物中，疫苗诱导的免疫反应被消除。
Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals.