In Vivo Three-Dimensional High Resolution Cardiac Diffusion-Weighted MRI: A Motion Compensated Diffusion-Prepared Balanced Steady-State Free Precession Approach
In Vivo Three-Dimensional High Resolution Cardiac Diffusion-Weighted MRI: A Motion Compensated Diffusion-Prepared Balanced Steady-State Free Precession Approach
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DOI：
10.1002/mrm.25038
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发表时间：
2014-11-01
影响因子：
3.3
通讯作者：
Li, Debiao
中科院分区：
文献类型：
--
作者：
Nguyen, Christopher;Fan, Zhaoyang;Li, Debiao
PurposeThe本研究的目的是实现和优化一种新的应用扩散准备平衡稳态自由进动（bSSFP）进行在体内心脏diffusion-weighted MRI.Theory and MethodsDiffusion-prepared序列具有灵活性的扩散编码与多拍摄图像读出。优化了扩散准备，以降低对二级运动补偿（M1 M2）心脏整体运动的敏感性。图像读出由三维（3D）中心编码分段bSSFP采集组成，其中包含前瞻性导航器。在不同的非共振条件下，使用拟定技术扩散制备（含和不含M1 M2），使用三个正交方向对10名健康受试者进行两次扫描。结果M1 M2弥散准备扫描的左心室trADC值为1.5 ± 0.4 × 10 - 3 mm 2/s，重复性好，无统计学差异（P = 0.54）。M1 M2扩散准备图像显示无重影伪影和/或信号衰减。非运动补偿扩散准备扫描产生的LV trADC值为6.6 +/- 0.9 × 10（-3）mm（2）/s和扩散准备的图像与严重的体积motion-induced artifacts.ConclusionWe开发了一种新的自由呼吸体积运动补偿扩散准备的3D分段bSSFP技术，能够在传统的临床MR扫描仪上进行体内心脏扩散加权MRI。Magn Reson Med 72：1257-1267，2014. (c)2013 Wiley Periodicals，Inc.
PurposeThe aim of this study was to implement and optimize a novel application of diffusion-prepared balanced steady-state free precession (bSSFP) to perform in vivo cardiac diffusion-weighted MRI.Theory and MethodsDiffusion-prepared sequences have the flexibility to diffusion encode with a multi-shot image readout. The diffusion preparation was optimized to reduce sensitivity to cardiac bulk motion with second order motion compensation (M1M2). The image readout consisted of a three-dimensional (3D) centric-encoded segmented bSSFP acquisition that incorporated a prospective navigator. Ten healthy subjects were scanned twice using the proposed technique diffusion preparation with and without M1M2 using three orthogonal directions under varying off-resonance conditions. Trace apparent diffusion coefficient (trADC) maps and the left ventricular (LV) trADC were calculated.ResultsM1M2 diffusion-prepared scans resulted in LV trADC values of 1.5 0.4 x 10(-3) mm(2)/s that were reproducible yielding no statistical differences (P = 0.54). M1M2 diffusion-prepared images showed no ghosting artifacts and/or signal fallout. The non-motion-compensated diffusion-prepared scans yielded LV trADC values of 6.6 +/- 0.9 x 10(-3) mm(2)/s and diffusion-prepared images with severe bulk motion-induced artifacts.ConclusionWe developed a novel free-breathing bulk motion compensated diffusion-prepared 3D segmented bSSFP technique able to perform in vivo cardiac diffusion-weighted MRI on a conventional clinical MR scanner. Magn Reson Med 72:1257-1267, 2014. (c) 2013 Wiley Periodicals, Inc.