Decreased pregnancy rate after in-vitro fertilization in HIV-infected women receiving HAART
Decreased pregnancy rate after in-vitro fertilization in HIV-infected women receiving HAART
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DOI：
10.1097/01.aids.0000196161.25647.35
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发表时间：
2006-01-02
期刊：
影响因子：
3.8
通讯作者：
Gatell, JM
中科院分区：
文献类型：
--
作者：
Coll, O;Suy, A;Gatell, JM
在感染艾滋病毒的妇女中进行了一项关于体外受精的研究。在这些患者中，如果使用患者自己的卵母细胞，则观察到IVF后的妊娠率降低。然而，如果使用捐赠的卵母细胞，则未发现妊娠率显著降低。CD4淋巴细胞计数与卵巢对过度刺激的抵抗独立相关。免疫抑制介导的亚临床性腺功能减退可以解释这些观察结果，这表明在考虑辅助生殖治疗之前需要优化患者的免疫状态。
A study on in-vitro fertilization (IVF) was conducted among HIV-infected women. In these patients, a reduced pregnancy rate after IVF was observed if the patient's own oocytes were used. However, no significant reduction in the pregnancy rate was found if donated oocytes were used. The CD4 lymphocyte count was independently associated with ovarian resistance to hyperstimulation. Subclinical hypogonadism mediated by immunosuppression may explain these observations, suggesting the need to optimize the immunological status of the patient before considering assisted reproduction treatments.