Annals of the New York Academy of Sciences Synaptic Pathways and Inhibitory Gates in the Spinal Cord Dorsal Horn
Annals of the New York Academy of Sciences Synaptic Pathways and Inhibitory Gates in the Spinal Cord Dorsal Horn
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A. N. Acad;Sci;T. Takazawa;A. MacDermott
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作者：
A. N. Acad;Sci;T. Takazawa;A. MacDermott
背角的抑制解除伴随着周围神经损伤，并导致对轻度刺激的超敏反应的发展。这证明了背角抑制对于维持正常感觉信号的至关重要性。在这里，我们表明，去抑制诱导一种新的多突触低阈值输入到第一层输出神经元，这表明抑制通常抑制预先存在的途径，可能有助于异常疼痛的感觉，如异常性疼痛。此外，我们发现，一个显着比例的浅层背角抑制神经元被激活的低阈值输入。这些神经元处于有利位置，有助于抑制板层I中疼痛输出神经元的低阈值激活。我们进一步讨论了几个方面的抑制在背角，可能有助于抑制病理信号。
Disinhibition in the dorsal horn accompanies peripheral nerve injury and causes the development of hypersensitivity to mild stimuli. This demonstrates the critical importance of inhibition in the dorsal horn for maintaining normal sensory signaling. Here we show that disinhibition induces a novel polysynaptic low-threshold input onto lamina I output neurons, suggesting that inhibition normally suppresses a preexisting pathway that probably contributes to abnormal pain sensations such as allodynia. In addition, we show that a significant proportion of superficial dorsal horn inhibitory neurons are activated by low-threshold input. These neurons are well situated to contribute to suppressing low-threshold activation of pain output neurons in lamina I. We further discuss several aspects of inhibition in the dorsal horn that might contribute to suppressing pathological signaling.