Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth
Relationship of periodontal bacteria and Porphyromonas gingivalis fimA variations with phenytoin-induced gingival overgrowth
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DOI：
10.1111/j.1601-0825.2005.01157.x
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发表时间：
2006-01-01
期刊：
影响因子：
3.8
通讯作者：
Morisaki, I
中科院分区：
文献类型：
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作者：
Akiyama, S;Amano, A;Morisaki, I
目的：我们调查了苯妥英诱导的牙龈过度生长（GO）和窝藏的牙周bacteria.MATERIALS和METHODS：牙周条件和龈下细菌配置文件进行了检查，在450个网站的75个科目之间的关系。采用聚合酶链反应（PCR）方法检测牙龈卟啉单胞菌（Pg）、伴放线放线杆菌（Aa）、嗜酸坦纳菌、齿垢密螺旋体（Td）、中间普雷沃菌（Pi）和变黑普雷沃菌（Pn）6种细菌。还检查了Pg fimA基因的遗传变异。细菌的发生与GO的严重程度进行了比较，并在细菌的发生率和数量的变化进行了监测牙周治疗following.Results：Aa，Td，Pi，Pn，和Pg与II型fimA（II型Pg）的发生与GO的严重程度显着相关。Td发生减少与牙龈改善超声洁治后，但是，没有观察到这样的关系与Aa，Pi，Pn和PG。此外，PG和Pi显着持续治疗后。临床改善的网站，Er：YAG激光治疗后，显着相关的定量减少Pg在改善的网站，但是，没有Pi。结论：II型Pg和Td分别被发现有一个显着的关系与GO的发展和恶化。
OBJECTIVES: We investigated the relationship between phenytoin-induced gingival overgrowth (GO) and the harboring of periodontal bacteria.MATERIALS AND METHODS: Periodontal conditions and subgingival bacterial profiles were examined in 450 sites of 75 subjects. A polymerase chain reaction method was used to detect six bacterial species; Porphyromonas gingivalis (Pg), Actinobacillus actinomycetemcomitans (Aa), Tannerella forsythia, Treponema denticola (Td), Prevotella intermedia (Pi), and Prevotella nigrescens (Pn). Genetic variations of the Pg fimA gene were also examined. Bacterial occurrence was compared with the severity of GO, and alterations in the bacterial occurrence rate and quantities were monitored following periodontal treatment.RESULTS: The occurrences of Aa, Td, Pi, Pn, and Pg with type II fimA (type II Pg) were significantly associated with the severity of GO. Td occurrence was reduced in association with gingival improvement following ultrasonic scaling, however, no such relationship was observed with Aa, Pi, Pn, and Pg. In addition, Pg and Pi markedly persisted after treatment. Clinical improvement of the sites, following an Er:YAG laser treatment, significantly associated with quantitative reduction of Pg in improved sites, however, not that of Pi.CONCLUSION: Type II Pg and Td were each found to have a significant relationship with the development and deterioration of GO.