SARS-CoV-2 Seroprevalence and Drug Use in Trauma Patients from Six Sites in the United States.
SARS-CoV-2 Seroprevalence and Drug Use in Trauma Patients from Six Sites in the United States.
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美国六个地点的创伤患者中 SARS-CoV-2 血清阳性率和药物使用情况。
DOI：
10.1101/2021.08.10.21261849
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发表时间：
2021
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作者：
Ngo,TranB;Karkanitsa,Maria;Adusei,KennethM;Graham,LindseyA;Ricotta,EmilyE;Darrah,JennaR;Blomberg,RichardD;Spathies,Jacquelyn;Pauly,KyleJ;Klumpp-Thomas,Carleen;Travers,Jameson;Mehalko,Jennifer;Drew,Matthew;Hall,MatthewD;
与一般患者群体相比，创伤患者的血源性传染病（例如肝炎和人类免疫缺陷病毒）的检测水平较高。与血源性病原体相比，目前尚不清楚创伤人群中 SARS-CoV-2 等呼吸道感染的流行情况以及其与药物使用和创伤类型等其他变量的关系。在这里，我们评估了 2020 年 4 月至 10 月第一波 COVID-19 大流行期间来自六个 1 级创伤中心的 2,542 名创伤患者的 SARS-CoV-2 血清阳性和抗体同种型谱。我们发现，18-44岁创伤受害者的血清阳性率（9.79%，95%置信区间/CI：8.33-11.47）远高于老年患者（45-69岁：6.03%，4.59-5.88；70岁以上：4.33%，2.54-7.20）。黑人/非裔美国人（9.54%，7.77 - 11.65）和西班牙裔/拉丁裔患者（14.95%，11.80 - 18.75）的血清阳性率也分别高于白人（5.72%，4.62 - 7.05）和非拉丁裔患者（6.55%，5.57 - 7.69）。超过一半（55.54%）的药物毒理学测试者的系统中至少存在一种药物。那些麻醉药或镇静剂检测呈阳性的人与血清阳性呈显着负相关，而那些服用抗抑郁药的人则呈阳性趋势。这些发现对于治疗面临 SARS-CoV-2 等呼吸道传染病潜在风险的创伤患者的患者和急救人员来说都是一个重要的考虑因素。
In comparison to the general patient population, trauma patients show higher level detections of bloodborne infectious diseases, such as Hepatitis and Human Immunodeficiency Virus. In comparison to bloodborne pathogens, the prevalence of respiratory infections such as SARS-CoV-2 and how that relates with other variables, such as drug usage and trauma type, is currently unknown in trauma populations. Here, we evaluated SARS-CoV-2 seropositivity and antibody isotype profile in 2,542 trauma patients from six Level-1 trauma centers between April and October of 2020 during the first wave of the COVID-19 pandemic. We found that the seroprevalence in trauma victims 18–44 years old (9.79%, 95% confidence interval/CI: 8.33 – 11.47) was much higher in comparison to older patients (45–69 years old: 6.03%, 4.59–5.88; 70+ years old: 4.33%, 2.54 – 7.20). Black/African American (9.54%, 7.77 – 11.65) and Hispanic/Latino patients (14.95%, 11.80 – 18.75) also had higher seroprevalence in comparison, respectively, to White (5.72%, 4.62 – 7.05) and Non-Latino patients (6.55%, 5.57 – 7.69). More than half (55.54%) of those tested for drug toxicology had at least one drug present in their system. Those that tested positive for narcotics or sedatives had a significant negative correlation with seropositivity, while those on anti-depressants trended positive. These findings represent an important consideration for both the patients and first responders that treat trauma patients facing potential risk of respiratory infectious diseases like SARS-CoV-2.