Immunoregulatory molecules are master regulators of inflammation during the immune response.
Immunoregulatory molecules are master regulators of inflammation during the immune response.
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DOI：
10.1016/j.febslet.2012.07.032
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发表时间：
2012-08-31
期刊：
影响因子：
3.5
通讯作者：
Sánchez-Madrid F
中科院分区：
文献类型：
--
作者：
de la Fuente H;Cibrián D;Sánchez-Madrid F
促炎和抗炎信号之间的平衡对于维持生理条件下的免疫稳态以及不同病理环境下的炎症控制至关重要。控制这种平衡的信号通路的最新进展导致了以免疫反应激活/抑制改变为特征的疾病的新型治疗剂的发展。不同的分子在免疫系统的调节中起关键作用，包括受体PD-1（程序性细胞死亡1）、CTLA-4（细胞毒性t淋巴细胞抗原4）和凝集素；或细胞内酶IDO（吲哚胺2,3-双加氧酶）。此外，其他分子如CD69、AhR（芳烃受体）和GADD45（生长阻滞和DNA损伤诱导45）家族成员，已成为调节免疫细胞激活/抑制平衡的潜在靶点。本文综述了在自身免疫性炎症疾病的背景下，已被充分表征的以及新出现的负免疫调节分子的观点。
The balance between pro- and anti-inflammatory signalling is critical to maintain the immune homeostasis under physiological conditions as well as for the control of inflammation in different pathological settings. Recent progress in the signalling pathways that control this balance has led to the development of novel therapeutic agents for diseases characterized by alterations in the activation/suppression of the immune response. Different molecules have a key role in the regulation of the immune system, including the receptors PD-1 (Programmed cell Death 1), CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) and galectins; or the intracellular enzyme IDO (indoleamine 2,3-dioxygenase). In addition, other molecules as CD69, AhR (Aryl hydrocarbon Receptor), and GADD45 (Growth Arrest and DNA Damage-inducible 45) family members, have emerged as potential targets for the regulation of the activation/suppression balance of immune cells. This review offers a perspective on well-characterized as well as emergent negative immune regulatory molecules in the context of autoimmune inflammatory diseases.
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影响因子：
37.8
作者：
Cruz-Adalia, Aranzazu;Jesus Jimenez-Borreguero, Luis;Martin, Pilar
通讯作者：
Martin, Pilar
DOI：
10.1164/rccm.200806-992oc
发表时间：
2009-06-01
影响因子：
24.7
作者：
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通讯作者：
Inoue, Hiromasa
DOI：
10.4049/jimmunol.0900291
发表时间：
2010-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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通讯作者：
Stenson WF
影响因子：
64.8
作者：
Dong, C;Juedes, AE;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
4.4
作者：
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通讯作者：
Cao, Xuetao